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PMID: 1743071 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A low-copy repeat located in subtelomeric regions of 14 different human chromosomal termini.

Cytogenetics and cell genetics ·Vol. 57 ·No. 4 ·1991-00-00 ·Pages 179-83

Weber B, Allen L, Magenis RE, Hayden MR

Abstract

Two cosmid clones, cG1A3 and cG1A6, containing large blocks of a telomeric repeat sequence, (TTAGGG)n, were isolated independently. Restriction mapping and fingerprinting studies suggested that cosmid cG1A6 is entirely contained within cG1A3. Competitive in situ hybridization localized cG1A3 to 14 different human telomeres and one internal site at 2q14----q21, indicating the presence of a subtelomeric low-copy repeat within this cosmid.

MeSH Terms

Base Sequence Blotting, Southern Chromosomes, Human, Pair 2 Cloning, Molecular Cosmids/genetics DNA Fingerprinting Fluorescence Humans Molecular Sequence Data Nucleic Acid Hybridization Repetitive Sequences, Nucleic Acid/genetics Restriction Mapping Telomere

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Weber B

Department of Medical Genetics, University of British Columbia, Vancouver, Canada.

Allen L

Magenis R E

Hayden M R

Article Info

Journal

Cytogenetics and cell genetics

Abbr.

Cytogenet Cell Genet

ISSN

0301-0171

DOI

10.1159/000133141

Published

1991-00-00

Pages

179-83

Language

English

Region

Switzerland

NLM ID

0367735

Subset

External Links

PubMed source DOI: 10.1159/000133141

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A low-copy repeat located in subtelomeric regions of 14 different human chromosomal termini.

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