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PMID: 17443395 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Modern biomaterials: a review - bulk properties and implications of surface modifications.

Journal of materials science. Materials in medicine ·Vol. 18 ·No. 7 ·2007-07-00 ·Pages 1263-77

Roach P, Eglin D, Rohde K, Perry CC

Abstract

This review concerns the importance of length and time on physicochemical interactions between living tissue and biomaterials that occur on implantation. The review provides information on material host interactions, materials for medical applications and cell surface interactions, and then details the extent of knowledge concerning the role(s) that surface chemistry and topography play during the first stage of implant integration, namely protein adsorption. The key points are illustrated by data from model in vitro studies. Host implant interactions begin nanoseconds after first contact and from then on are in a state of flux due to protein adsorption, cell adhesion and physical and chemical alteration of the implanted material. The many questions concerning the conformational form and control of bound proteins and how this may impact on cell adhesion in the first instance and later on cell signalling and implant integration can be answered by systematic investigations using model materials. Only then we will be in a more informed position to design new materials for use in the body.

MeSH Terms
Adsorption Biocompatible Materials/chemistry,metabolism Cell Adhesion/physiology Cell Culture Techniques/methods Prostheses and Implants Proteins/chemistry,metabolism Surface Properties
Chemicals
Biocompatible Materials Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Roach Paul
Division of Chemistry, Interdisciplinary Biomedical Research Centre, School of Biomedical and Natural Sciences, Nottingham Trent University, Clifton, Nottingham, UK.
Eglin David
Rohde Kirsty
Perry Carole C
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Article Info
Journal
Journal of materials science. Materials in medicine
Abbr.
J Mater Sci Mater Med
ISSN
0957-4530
DOI
10.1007/s10856-006-0064-3
Published
2007-07-00
Epub
2007-00-19
Pages
1263-77
Language
English
Region
United States
NLM ID
9013087
Subset
IM
External Links
PubMed source DOI: 10.1007/s10856-006-0064-3 View journal details
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