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PMID: 17449449 Published · ppublish English Journal Article Review

From dopaminergic genes to psychiatric disorders.

Neurotoxicity research ·Vol. 11 ·No. 1 ·2007-01-00 ·Pages 61-72

Hoenicka J, Aragüés M, Ponce G, Rodríguez-Jiménez R, Jiménez-Arriero MA, Palomo T

Abstract

Individual vulnerability to develop neurological and psychiatric disorders is associated with both genetic and environmental factors. Association studies in patients have explored the contribution of gene variants in the dopaminergic system in these disorders. This system is involved in motor control, endocrinological function, the reward system and cognition. The diverse physiological functions of dopamine are mediated by five different dopamine receptors, encoded by the genes DRD1, DRD2, DRD3, DRD4 and DRD5. These genes have various types of polymorphisms that can produce changes in the genetic product or expression levels. In recent years, the development of new technologies for genetic analysis, and a wider comprehension of the genetic sequences of these genes have increased our understanding of the implications of the dopaminergic system in both health and pathological states. It has also allowed the identification of genetic variants that may represent risk or protection factors for a variety of psychiatric disorders.

MeSH Terms
Animals Dopamine/genetics,physiology Humans Mental Disorders/genetics Receptors, Dopamine/genetics,physiology Receptors, Dopamine D1/genetics,physiology Receptors, Dopamine D2/genetics,physiology Receptors, Dopamine D3/genetics,physiology Receptors, Dopamine D4/genetics,physiology Receptors, Dopamine D5/genetics,physiology
Chemicals
Receptors, Dopamine Receptors, Dopamine D1 Receptors, Dopamine D2 Receptors, Dopamine D3 Receptors, Dopamine D4 Receptors, Dopamine D5 Dopamine
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Hoenicka Janet
Unidad de Conductas Adictivas, Servicio de Psiquiatría, Hospital Universitario 12 de Octubre, Av. de Córdoba s/n, Madrid 28041, Spain. [email protected]
Aragüés María
Ponce Guillermo
Rodríguez-Jiménez Roberto
Jiménez-Arriero Miguel A
Palomo Tomás
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Article Info
Journal
Neurotoxicity research
Abbr.
Neurotox Res
ISSN
1029-8428
DOI
10.1007/BF03033483
Email
[email protected]
Published
2007-01-00
Pages
61-72
Language
English
Region
United States
NLM ID
100929017
Subset
IM
External Links
PubMed source DOI: 10.1007/BF03033483 View journal details
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