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PMID: 17461453 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Risk factors for Barrett's oesophagus and oesophageal adenocarcinoma: results from the FINBAR study.

World journal of gastroenterology ·Vol. 13 ·No. 10 ·2007-03-14 ·Pages 1585-94

Anderson LA, Watson RG, Murphy SJ, Johnston BT, Comber H, Mc Guigan J, Reynolds JV, Murray LJ

Abstract

To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma. This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients, 227 oesophageal adenocarcinoma patients and 260 controls. All participants underwent a structured interview with information obtained about potential lifestyle and environmental risk factors. Gastro-oesophageal reflux was associated with Barrett's [OR 12.0 (95% CI 7.64-18.7)] and oesophageal adenocarcinoma [OR 3.48 (95% CI 2.25-5.41)]. Oesophageal adenocarcinoma patients were more likely than controls to be ex- or current smokers [OR 1.72 (95% CI 1.06-2.81) and OR 4.84 (95% CI 2.72-8.61) respectively] and to have a high body mass index [OR 2.69 (95% CI 1.62-4.46)]. No significant associations were observed between these risk factors and Barrett's oesophagus. Fruit but not vegetables were negatively associated with oesophageal adenocarcinoma [OR 0.50 (95% CI 0.30-0.86)]. A high body mass index, a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinoma.

MeSH Terms
Adenocarcinoma/epidemiology Aged Barrett Esophagus/epidemiology Body Mass Index Case-Control Studies Diet Disease Progression Esophageal Neoplasms/epidemiology Female Fruit Gastroesophageal Reflux/complications,etiology Humans Male Middle Aged Northern Ireland Risk Factors Smoking/adverse effects
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Anderson Lesley A
Centre for Clinical and Population Sciences, Queen's University, Mulhouse Building, Grosvenor Road, Belfast, BT12 6BJ, Northern Ireland. [email protected]
Watson R G Peter
Murphy Seamus J
Johnston Brian T
Comber Harry
Mc Guigan Jim
Reynolds John V
Murray Liam J
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Article Info
Journal
World journal of gastroenterology
Abbr.
World J Gastroenterol
ISSN
1007-9327
DOI
10.3748/wjg.v13.i10.1585
Email
[email protected]
Published
2007-03-14
Pages
1585-94
Language
English
Region
United States
NLM ID
100883448
PMCID
PMC4146903
Subset
IM
External Links
PubMed source DOI: 10.3748/wjg.v13.i10.1585 PMC Full Text View journal details
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