A two-way street: LSD1 regulates chromatin boundary formation in S. pombe and Drosophila.

Molecular cell ·Vol. 26 ·No. 2 ·2007-04-27 ·Pages 160-2

Chosed R, Dent SY

Abstract

Two recent studies in Molecular Cell (Lan et al., 2007; Rudolph et al., 2007) implicate histone demethylation by LSD1 in the regulation of boundaries between silenced and active chromatin domains in both fission yeast and flies, but by distinct mechanisms.

MeSH Terms

Animals Chromatin/enzymology,genetics Drosophila Proteins/genetics,metabolism Drosophila melanogaster/enzymology,genetics Euchromatin/enzymology,genetics Genes, Fungal Genes, Insect Heterochromatin/enzymology,genetics Histones/metabolism Models, Biological Oxidoreductases, N-Demethylating/genetics,metabolism Schizosaccharomyces/enzymology,genetics Schizosaccharomyces pombe Proteins/genetics,metabolism

Chemicals

Chromatin Drosophila Proteins Euchromatin Heterochromatin Histones Schizosaccharomyces pombe Proteins Oxidoreductases, N-Demethylating

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Chosed Renee

Program in Genes and Development, Department of Biochemistry and Molecular Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

Dent Sharon Y R

Article Info

Journal

Molecular cell

Abbr.

Mol Cell

ISSN

1097-2765

DOI

10.1016/j.molcel.2007.04.009

Published

2007-04-27

Pages

160-2

Language

English

Region

United States

NLM ID

9802571

Subset

Corrections

CommentOn

PMID: 17434129

CommentOn

PMID: 17434130

External Links

PubMed source DOI: 10.1016/j.molcel.2007.04.009 View journal details

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A two-way street: LSD1 regulates chromatin boundary formation in S. pombe and Drosophila.

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