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PMID: 17470632 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.

The Journal of cell biology ·Vol. 177 ·No. 3 ·2007-05-07 ·Pages 489-500

Ball SG, Shuttleworth CA, Kielty CM

Abstract

Vascular endothelial growth factor (VEGF-A) is a crucial stimulator of vascular cell migration and proliferation. Using bone marrow-derived human adult mesenchymal stem cells (MSCs) that did not express VEGF receptors, we provide evidence that VEGF-A can stimulate platelet-derived growth factor receptors (PDGFRs), thereby regulating MSC migration and proliferation. VEGF-A binds to both PDGFRalpha and PDGFRbeta and induces tyrosine phosphorylation that, when inhibited, results in attenuation of VEGF-A-induced MSC migration and proliferation. This mechanism was also shown to mediate human dermal fibroblast (HDF) migration. VEGF-A/PDGFR signaling has the potential to regulate vascular cell recruitment and proliferation during tissue regeneration and disease.

MeSH Terms
Adolescent Adult Bone Marrow Cells/cytology,metabolism Cell Movement/drug effects,physiology Cells, Cultured Dermis/cytology,metabolism Female Fibroblasts/cytology,metabolism Humans Infant, Newborn Male Mesenchymal Stem Cells/cytology,metabolism Protein Binding/physiology Receptor, Platelet-Derived Growth Factor alpha/metabolism Receptor, Platelet-Derived Growth Factor beta/metabolism Regeneration/drug effects,physiology Signal Transduction/drug effects,physiology Vascular Endothelial Growth Factor A/metabolism,pharmacology
Chemicals
VEGFA protein, human Vascular Endothelial Growth Factor A Receptor, Platelet-Derived Growth Factor alpha Receptor, Platelet-Derived Growth Factor beta
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ball Stephen G
UK Centre for Tissue Engineering and 2Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, England, UK.
Shuttleworth C Adrian
Kielty Cay M
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.200608093
Published
2007-05-07
Epub
2007-00-30
Pages
489-500
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2064818
Subset
IM
Grants
Medical Research Council · G0700712 · United Kingdom
External Links
PubMed source DOI: 10.1083/jcb.200608093 PMC Full Text View journal details
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