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PMID: 174935 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Adenovirus type 12 infection of defined mouse-human hybrid cell clones.

Experientia ·Vol. 32 ·No. 1 ·1976-01-15 ·Pages 38-40

Biron KK, Raska K

Abstract

Human adenovirus type 12 does not multiply in mouse cells; only viral T-antigen is detected. Mouse-human cell hybrid clones containing human chromosomes A3, B5, C7, C11, C12, D14, E17, F19 and F20, support synthesis of adenovirus DNA and capsid antigens.

MeSH Terms
Adenoviridae/metabolism Adenoviridae Infections Animals Antigens, Viral/analysis Clone Cells/metabolism DNA, Viral/biosynthesis Fibroblasts/metabolism Humans Hybrid Cells/metabolism Mice Phosphates/metabolism Thymidine/metabolism
Chemicals
Antigens, Viral DNA, Viral Phosphates Thymidine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Biron K K
Raska K
References (9)
9 references, click to expand
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    Nat New Biol. 1973 Feb 7;241(110):180-2 PMID: 4512579
  2. Human-mouse hybrid cell lines and susceptibility to species-specific viruses.
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  3. The response of BHK21 cells to infection with type 12 adenovirus. 1. Cell killing and T antigen synthesis as correlated viral genome functions.
    Virology. 1969 Dec;39(4):642-52 PMID: 4902254
  4. Human regulatory gene for inducible tyrosine aminotransferase in rat-human hybrids.
    Proc Natl Acad Sci U S A. 1973 Apr;70(4):1268-72 PMID: 4146214
  5. Preferential retention of the human chromosome C-7 in human-(thymidine kinase deficient) mouse hybrid cells.
    Exp Cell Res. 1973 Dec;82(2):457-61 PMID: 4358117
  6. Editorial: The gene for the poliovirus receptor.
    N Engl J Med. 1974 May 2;290(18):1018-9 PMID: 4362083
  7. Effect of arginine starvation on macromolecular synthesis in infection with type 2 adenovirus. II. Synthesis of virus-specific RNA and DNA.
    Virology. 1972 May;48(2):472-84 PMID: 4337031
  8. Synthesis of viral components in hybrids of differentially permissive cells infected with adenovirus type 12.
    Exp Cell Res. 1972 Oct;74(2):423-9 PMID: 4343019
  9. Assignment of the T-antigen gene of simian virus 40 to human chromosome C-7.
    Proc Natl Acad Sci U S A. 1973 Dec;70(12):3617-20 PMID: 4357883
Article Info
Journal
Experientia
Abbr.
Experientia
ISSN
0014-4754
DOI
10.1007/BF01932611
Published
1976-01-15
Pages
38-40
Language
English
Region
Switzerland
NLM ID
0376547
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01932611
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