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PMID: 17496892 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Variation in FTO contributes to childhood obesity and severe adult obesity.

Nature genetics ·Vol. 39 ·No. 6 ·2007-06-00 ·Pages 724-6

Dina C, Meyre D, Gallina S, Durand E, Körner A, Jacobson P, Carlsson LM, Kiess W, Vatin V, Lecoeur C, Delplanque J, Vaillant E, Pattou F, Ruiz J, Weill J, Levy-Marchal C, Horber F, Potoczna N, Hercberg S, Le Stunff C, Bougnères P, Kovacs P, Marre M, Balkau B, Cauchi S, Chèvre JC, Froguel P

Abstract

We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 x 10(-26) in 2,900 affected individuals and 5,100 controls. The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.

MeSH Terms
Adiposity Adult Age of Onset Body Composition Body Mass Index Case-Control Studies Child Chromosomes, Human, Pair 16/genetics Cohort Studies Europe Female Genetic Predisposition to Disease Genetic Variation/genetics Humans Introns/genetics Male Middle Aged Obesity/genetics Polymorphism, Single Nucleotide/genetics
Authors & Affiliations
27 authors, click to expand affiliations / ORCID
Dina Christian
CNRS 8090-Institute of Biology, Pasteur Institute, Lille, France. [email protected]
Meyre David
Gallina Sophie
Durand Emmanuelle
Körner Antje
Jacobson Peter
Carlsson Lena M S
Kiess Wieland
Vatin Vincent
Lecoeur Cecile
Delplanque Jérome
Vaillant Emmanuel
Pattou François
Ruiz Juan
Weill Jacques
Levy-Marchal Claire
Horber Fritz
Potoczna Natascha
Hercberg Serge
Le Stunff Catherine
Bougnères Pierre
Kovacs Peter
Marre Michel
Balkau Beverley
Cauchi Stéphane
Chèvre Jean-Claude
Froguel Philippe
Article Info
Journal
Nature genetics
Abbr.
Nat Genet
ISSN
1061-4036
DOI
10.1038/ng2048
Email
[email protected]
Published
2007-06-00
Epub
2007-00-13
Pages
724-6
Language
English
Region
United States
NLM ID
9216904
Subset
IM
Grants
Medical Research Council · G0000477 · United Kingdom
Medical Research Council · G0600331 · United Kingdom
Corrections
CommentIn
PMID: 17534362
CommentIn
PMID: 24951667
External Links
PubMed source DOI: 10.1038/ng2048 View journal details
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