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PMID: 175019 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Inhibition of lipopolysaccharide-initiated activation of serum complement by polymyxin B.

Infection and immunity ·Vol. 13 ·No. 1 ·1976-01-00 ·Pages 298-301

Morrison DC, Jacobs DM

Abstract

Treatment of bacterial lipopolysaccharides (endotoxins) isolated from Salmonella minnesota R595 or purified lipid A with the antibiotic polymyxin B has been demonstrated to abrogate the ability of these molecules to activate serum complement. The inhibition is a function of the ratio of polymyxin B to lipopolysaccharide.

MeSH Terms

Animals Complement System Proteins/physiology Hemolysis/drug effects Lipopolysaccharides/antagonists & inhibitors Polymyxins/pharmacology Polysaccharides, Bacterial/antagonists & inhibitors Rabbits Salmonella

Chemicals

Lipopolysaccharides Polymyxins Polysaccharides, Bacterial Complement System Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Morrison D C

Jacobs D M

References (15)

15 references, click to expand

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Dissociation between mitogenicity and immunogenicity of TNP-lipopolysaccharide, a T-independent antigen.
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The role of complement in endotoxin shock and disseminated intravascular coagulation: experimental observations in the dog.
Br J Haematol. 1974 Nov;28(3):393-401 PMID: 4216363
Depletion of plasma complement in vivo by a protein of cobra venom: its effect on various immunologic reactions.
J Immunol. 1970 Jul;105(1):55-69 PMID: 4246566
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J Bacteriol. 1966 Oct;92(4):815-9 PMID: 4288800
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J Bacteriol. 1967 Apr;93(4):1463-4 PMID: 4291769
Endotoxin-induced intravascular coagulation: prevention with polymyxin B sulfate.
J Lab Clin Med. 1971 May;77(5):802-10 PMID: 4326749
Neutralization of the hemodynamic effects of endotoxin by polymyxin B.
Surg Gynecol Obstet. 1974 May;138(5):755-9 PMID: 4362912
Interaction of complex polysaccharides with the complement system: effect of calcium depletion on terminal component consumption.
Infect Immun. 1975 Feb;11(2):273-9 PMID: 46215
Neutralization of the Shwartzman reactions by polymyxins B.
J Immunol. 1967 Sep;99(3):564-9 PMID: 4862203
Interaction of lipopolysaccharides and lipid A with complement.
Eur J Biochem. 1971 Mar 1;19(1):143-52 PMID: 4927998
Interactions of the complement system with endotoxins from a Salmonella minnesota mutant deficient in O-polysaccharide and heptose.
J Immunol. 1968 Jan;100(1):227-9 PMID: 5635624
A new method for the extraction of R lipopolysaccharides.
Eur J Biochem. 1969 Jun;9(2):245-9 PMID: 5804498
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J Exp Med. 1962 Oct 1;116:477-90 PMID: 13947829

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.13.1.298-301.1976

Published

1976-01-00

Pages

298-301

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC420610

Subset

External Links

PubMed source DOI: 10.1128/iai.13.1.298-301.1976 PMC Full Text View journal details

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Inhibition of lipopolysaccharide-initiated activation of serum complement by polymyxin B.

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