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PMID: 17529973 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural

A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer.

Nature genetics ·Vol. 39 ·No. 7 ·2007-07-00 ·Pages 870-4

Hunter DJ, Kraft P, Jacobs KB, Cox DG, Yeager M, Hankinson SE, Wacholder S, Wang Z, Welch R, Hutchinson A, Wang J, Yu K, Chatterjee N, Orr N, Willett WC, Colditz GA, Ziegler RG, Berg CD, Buys SS, McCarty CA, Feigelson HS, Calle EE, Thun MJ, Hayes RB, Tucker M, Gerhard DS, Fraumeni JF, Hoover RN, Thomas G, Chanock SJ

Abstract

We conducted a genome-wide association study (GWAS) of breast cancer by genotyping 528,173 SNPs in 1,145 postmenopausal women of European ancestry with invasive breast cancer and 1,142 controls. We identified four SNPs in intron 2 of FGFR2 (which encodes a receptor tyrosine kinase and is amplified or overexpressed in some breast cancers) that were highly associated with breast cancer and confirmed this association in 1,776 affected individuals and 2,072 controls from three additional studies. Across the four studies, the association with all four SNPs was highly statistically significant (P(trend) for the most strongly associated SNP (rs1219648) = 1.1 x 10(-10); population attributable risk = 16%). Four SNPs at other loci most strongly associated with breast cancer in the initial GWAS were not associated in the replication studies. Our summary results from the GWAS are available online in a form that should speed the identification of additional risk loci.

MeSH Terms
Aged Alleles Breast Neoplasms/genetics Female Genetic Predisposition to Disease Genome, Human Humans Middle Aged Polymorphism, Single Nucleotide Postmenopause Receptor, Fibroblast Growth Factor, Type 2/genetics Risk Factors
Chemicals
FGFR2 protein, human Receptor, Fibroblast Growth Factor, Type 2
Authors & Affiliations
30 authors, click to expand affiliations / ORCID
Hunter David J
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. [email protected]
Kraft Peter
Jacobs Kevin B
Cox David G
Yeager Meredith
Hankinson Susan E
Wacholder Sholom
Wang Zhaoming
Welch Robert
Hutchinson Amy
Wang Junwen
Yu Kai
Chatterjee Nilanjan
Orr Nick
Willett Walter C
Colditz Graham A
Ziegler Regina G
Berg Christine D
Buys Saundra S
McCarty Catherine A
Feigelson Heather Spencer
Calle Eugenia E
Thun Michael J
Hayes Richard B
Tucker Margaret
Gerhard Daniela S
Fraumeni Joseph F
Hoover Robert N
Thomas Gilles
Chanock Stephen J
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Article Info
Journal
Nature genetics
Abbr.
Nat Genet
ISSN
1061-4036
DOI
10.1038/ng2075
Email
[email protected]
Published
2007-07-00
Epub
2007-00-27
Pages
870-4
Language
English
Region
United States
NLM ID
9216904
PMCID
PMC3493132
Subset
IM
Grants
NCI NIH HHS · R01 CA050385 · United States
NCI NIH HHS · P01 CA087969 · United States
NCI NIH HHS · R01 CA067262 · United States
NCI NIH HHS · 5U01CA098233 · United States
NCI NIH HHS · CA87969 · United States
NCI NIH HHS · CA49449 · United States
NCI NIH HHS · U01 CA067262 · United States
NCI NIH HHS · R01 CA065725 · United States
NCI NIH HHS · CA67262 · United States
Intramural NIH HHS · United States
NCI NIH HHS · U01 CA098233 · United States
NCI NIH HHS · R01 CA049449 · United States
NCI NIH HHS · CA50385 · United States
NCI NIH HHS · U01 CA049449 · United States
NCI NIH HHS · U01 CA098710 · United States
NCI NIH HHS · CA65725 · United States
External Links
PubMed source DOI: 10.1038/ng2075 PMC Full Text View journal details
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