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PMID: 17536174 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Thermosensors in eubacteria: role and evolution.

Journal of biosciences ·Vol. 32 ·No. 3 ·2007-04-00 ·Pages 549-57

Schumann W

Abstract

Temperature is an important physical stress factor sensed by bacteria and used to regulate gene expression. Three different macromolecules have been identified being able to sense temperature: DNA, mRNA and proteins. Depending on the induction mechanism, two different pathways have to be distinguished, namely the heat shock response and the high temperature response. While the heat shock response is induced by temperature increments and is transient, the high temperature response needs a specific temperature to become induced and proceeds as long as cells are exposed to that temperature. The heat shock response is induced by denatured proteins and aimed to prevent formation of protein aggregates by refolding or degradation, and the high temperature response is mainly used by pathogenic bacteria to detect entry into a mammalian host followed by induction of their virulence genes. All known high temperature sensors are present in two alternative conformations depending on the temperature. Heat shock sensors are either molecular chaperones or proteases which keep either a positive transcriptional regulator inactive or a negative regulator active or do not attack the regulator, respectively, under physiological conditions. Denatured proteins either titrate the molecular chaperones or activate the protease. The evolution of the different temperature sensors is discussed.

MeSH Terms
Adaptation, Physiological Bacteria/genetics,metabolism Biological Evolution Body Temperature Regulation Hot Temperature
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Schumann Wolfgang
Institute of Genetics, University of Bayreuth, D-95440 Bayreuth, Germany. [email protected]
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Article Info
Journal
Journal of biosciences
Abbr.
J Biosci
ISSN
0250-5991
DOI
10.1007/s12038-007-0054-8
Email
[email protected]
Published
2007-04-00
Pages
549-57
Language
English
Region
India
NLM ID
8100809
Subset
IM
External Links
PubMed source DOI: 10.1007/s12038-007-0054-8 View journal details
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