Structure-function correlations in erythropoietin formation and oxygen sensing in the kidney.

Klinische Wochenschrift ·Vol. 69 ·No. 13 ·1991-09-03 ·Pages 567-75

Le Hir M, Eckardt KU, Kaissling B, Koury ST, Kurtz A

Abstract

The kidney is the main site of erythropoietin (EPO) formation. Oxygen sensing in the kidney itself plays a major role in the control of EPO synthesis. By in situ hybridization it has been established that the EPO-producing cells are situated in the interstitium of the cortical labyrinth, but they have not been precisely identified. Morphological findings provide new insights into the location and mechanism of oxygen sensing in the kidney. In addition to causing an increase in the number of cells containing EPO messenger RNA, anemia provokes structural changes exclusively in the cortical labyrinth. Specifically, the fibroblasts become enlarged and show increased activity of 5'-nucleotidase, and the S1 segment of the proximal tubule shows similar alterations as in various models of hypoxia. Thus, structures that are situated in the close vicinity of the EPO-producing cells appear to be sensitive to decreased oxygen delivery.

MeSH Terms

Anemia/blood,pathology Animals Endothelium, Vascular/pathology,physiopathology Erythropoietin/biosynthesis Humans Hypoxia/blood,pathology Kidney/pathology,physiopathology Kidney Tubules, Proximal/pathology,physiopathology Oxygen/blood

Chemicals

Erythropoietin Oxygen

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Le Hir M

Medizinische Universitätspoliklinik, Kantonsspital Basel.

Eckardt K U

Kaissling B

Koury S T

Kurtz A

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Article Info

Journal

Klinische Wochenschrift

Abbr.

Klin Wochenschr

ISSN

0023-2173

DOI

10.1007/BF01649319

Published

1991-09-03

Pages

567-75

Language

English

Region

Germany

NLM ID

2985205R

Subset

External Links

PubMed source DOI: 10.1007/BF01649319

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Structure-function correlations in erythropoietin formation and oxygen sensing in the kidney.

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