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PMID: 17543136 Published · ppublish English Journal Article Review

The integrins.

Genome biology ·Vol. 8 ·No. 5 ·2007-00-00 ·Pages 215

Takada Y, Ye X, Simon S

Abstract

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands. They are transmembrane alphabeta heterodimers and at least 18 alpha and eight beta subunits are known in humans, generating 24 heterodimers. Members of this family have been found in mammals, chicken and zebrafish, as well as lower eukaryotes, including sponges, the nematode Caenorhabditis elegans (two alpha and one beta subunits, generating two integrins) and the fruitfly Drosophila melanogaster (five alpha and one beta, generating five integrins). The alpha and beta subunits have distinct domain structures, with extracellular domains from each subunit contributing to the ligand-binding site of the heterodimer. The sequence arginine-glycine-aspartic acid (RGD) was identified as a general integrin-binding motif, but individual integrins are also specific for particular protein ligands. Immunologically important integrin ligands are the intercellular adhesion molecules (ICAMs), immunoglobulin superfamily members present on inflamed endothelium and antigen-presenting cells. On ligand binding, integrins transduce signals into the cell interior; they can also receive intracellular signals that regulate their ligand-binding affinity. Here we provide a brief overview that concentrates mostly on the organization, structure and function of mammalian integrins, which have been more extensively studied than integrins in other organisms.

MeSH Terms
Animals Humans Integrins/chemistry,metabolism,physiology Ligands Protein Binding Protein Subunits Signal Transduction
Chemicals
Integrins Ligands Protein Subunits
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Takada Yoshikazu
Department of Dermatology, University of California Davis School of Medicine, Second Avenue, Sacramento, CA 95817, USA. [email protected]
Ye Xiaojing
Simon Scott
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Article Info
Journal
Genome biology
Abbr.
Genome Biol
ISSN
1474-760X
Published
2007-00-00
Pages
215
Language
English
Region
England
NLM ID
100960660
PMCID
PMC1929136
Subset
IM
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