Energy regulation: HIF MXIes it up with the C-MYC powerhouse.

Developmental cell ·Vol. 12 ·No. 6 ·2007-06-00 ·Pages 845-6

Sutphin PD, Giaccia AJ, Chan DA

Abstract

The phenomenon of aerobic glycolysis observed in cancer cells has remained unexplained. In the May 2007 issue of Cancer Cell, Zhang and colleagues determine that the hypoxia-inducible factor family of transcriptional factors regulate mitochondrial biogenesis through inhibition of C-MYC.

MeSH Terms

Basic Helix-Loop-Helix Transcription Factors/metabolism Energy Metabolism Humans Hypoxia-Inducible Factor 1, alpha Subunit/metabolism Mitochondria/metabolism Neoplasms/genetics,metabolism,pathology Oxygen/metabolism Proto-Oncogene Proteins c-myc/antagonists & inhibitors,physiology Transcription, Genetic/physiology Tumor Suppressor Proteins/metabolism Von Hippel-Lindau Tumor Suppressor Protein/metabolism

Chemicals

Basic Helix-Loop-Helix Transcription Factors HIF1A protein, human Hypoxia-Inducible Factor 1, alpha Subunit MXI1 protein, human Proto-Oncogene Proteins c-myc Tumor Suppressor Proteins Von Hippel-Lindau Tumor Suppressor Protein VHL protein, human Oxygen

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Sutphin Patrick D

Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.

Giaccia Amato J

Chan Denise A

Article Info

Journal

Developmental cell

Abbr.

Dev Cell

ISSN

1534-5807

DOI

10.1016/j.devcel.2007.05.006

Published

2007-06-00

Pages

845-6

Language

English

Region

United States

NLM ID

101120028

Subset

External Links

PubMed source DOI: 10.1016/j.devcel.2007.05.006 View journal details

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Energy regulation: HIF MXIes it up with the C-MYC powerhouse.

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