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PMID: 17555829 Published · ppublish English Journal Article Review

Raf kinases: function, regulation and role in human cancer.

Biochimica et biophysica acta ·Vol. 1773 ·No. 8 ·2007-08-00 ·Pages 1196-212

Leicht DT, Balan V, Kaplun A, Singh-Gupta V, Kaplun L, Dobson M, Tzivion G

Abstract

The Ras-Raf-MAPK pathway regulates diverse physiological processes by transmitting signals from membrane based receptors to various nuclear, cytoplasmic and membrane-bound targets, coordinating a large variety of cellular responses. Function of Raf family kinases has been shown to play a role during organism development, cell cycle regulation, cell proliferation and differentiation, cell survival and apoptosis and many other cellular and physiological processes. Aberrations along the Ras-Raf-MAPK pathway play an integral role in various biological processes concerning human health and disease. Overexpression or activation of the pathway components is a common indicator in proliferative diseases such as cancer and contributes to tumor initiation, progression and metastasis. In this review, we focus on the physiological roles of Raf kinases in normal and disease conditions, specifically cancer, and the current thoughts on Raf regulation.

MeSH Terms
Amino Acid Sequence Animals Apoptosis Cell Differentiation Cells, Cultured Humans Invertebrates Mice Mice, Knockout Mice, Transgenic Models, Biological Molecular Sequence Data Neoplasms/enzymology,etiology,genetics,therapy Oncogenes Sequence Homology, Amino Acid Signal Transduction raf Kinases/antagonists & inhibitors,chemistry,genetics,physiology
Chemicals
raf Kinases
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Leicht Deborah T
Karmanos Cancer Institute and Department of Pathology, Wayne State University, Detroit, MI 4820, USA.
Balan Vitaly
Kaplun Alexander
Singh-Gupta Vinita
Kaplun Ludmila
Dobson Melissa
Tzivion Guri
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Article Info
Journal
Biochimica et biophysica acta
Abbr.
Biochim Biophys Acta
ISSN
0006-3002
DOI
10.1016/j.bbamcr.2007.05.001
Published
2007-08-00
Epub
2007-00-22
Pages
1196-212
Language
English
Region
Netherlands
NLM ID
0217513
PMCID
PMC1986673
Subset
IM
Grants
NIGMS NIH HHS · R01 GM067134 · United States
NIGMS NIH HHS · R01 GM067134-05 · United States
External Links
PubMed source DOI: 10.1016/j.bbamcr.2007.05.001 PMC Full Text
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