Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family.

Amino Acid Substitution Animals Apoptosis Apoptosis Regulatory Proteins/chemistry,metabolism Bcl-2-Like Protein 11 Biphenyl Compounds/chemistry,metabolism Humans Membrane Proteins/chemistry,metabolism Mice Nitrophenols/chemistry,metabolism Piperazines/chemistry,metabolism Protein Structure, Tertiary Proto-Oncogene Proteins/chemistry,metabolism Sulfonamides/chemistry,metabolism bcl-X Protein/chemistry,metabolism

ABT-737 Apoptosis Regulatory Proteins BCL2L1 protein, human BCL2L11 protein, human Bcl-2-Like Protein 11 Bcl2l11 protein, mouse Biphenyl Compounds Membrane Proteins Nitrophenols Piperazines Proto-Oncogene Proteins Sulfonamides bcl-X Protein