Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate.

Movement disorders : official journal of the Movement Disorder Society ·Vol. 6 ·No. 4 ·1991-00-00 ·Pages 288-92

Aziz TZ, Peggs D, Sambrook MA, Crossman AR

Abstract

Central to the neural mechanism of MPTP-induced parkinsonism is overactivity of the subthalamic nucleus. Lesion of the subthalamic nucleus has therefore been performed in two primates with this condition and found to produce a remarkable amelioration of the disorder.

MeSH Terms

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Brain Mapping Dominance, Cerebral/drug effects,physiology Macaca fascicularis Neurologic Examination Parkinson Disease, Secondary/chemically induced,physiopathology,surgery Radiosurgery Thalamic Nuclei/physiopathology,surgery

Chemicals

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Aziz T Z

Department of Cell and Structural Biology, University of Manchester Medical School, U.K.

Peggs D

Sambrook M A

Crossman A R

Article Info

Journal

Movement disorders : official journal of the Movement Disorder Society

Abbr.

Mov Disord

ISSN

0885-3185

DOI

10.1002/mds.870060404

Published

1991-00-00

Pages

288-92

Language

English

Region

United States

NLM ID

8610688

Subset

External Links

PubMed source DOI: 10.1002/mds.870060404 View journal details

Analysis Services

Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate.

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