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PMID: 17584839 Published · ppublish English Journal Article Review

Phospholipases and fatty acid signalling in exocytosis.

The Journal of physiology ·Vol. 585 ·No. Pt 3 ·2007-12-15 ·Pages 699-704

Darios F, Connell E, Davletov B

Abstract

Vesicle fusion is a ubiquitous biological process involved in general membrane trafficking and a variety of specialized events, for example release of neurotransmitters and hormones, sperm acrosome exocytosis, plasma membrane repair and neurite outgrowth. Many vesicle fusion events have long been known to be activated by phospholipases and products of their activity, such as polyunsaturated arachidonic acid. Polyunsaturated fatty acids (PUFAs) have been proposed to have a number of multiple effectors, including ion channels and the cytoskeleton, but the precise mechanism of PUFA action is still unclear. It was recently reported that omega-3 and omega-6 PUFAs can act on syntaxin, a plasma membrane protein directly involved in vesicle fusion. In this review, we will discuss the role of this new mode of PUFA action in exocytosis.

MeSH Terms
Animals Cell Membrane/enzymology,ultrastructure Exocytosis/physiology Fatty Acids/physiology Fatty Acids, Unsaturated/physiology Humans Neurons/physiology Phospholipases/physiology Qa-SNARE Proteins/physiology Signal Transduction/physiology
Chemicals
Fatty Acids Fatty Acids, Unsaturated Qa-SNARE Proteins Phospholipases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Darios Frédéric
MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK.
Connell Emma
Davletov Bazbek
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.2007.136812
Published
2007-12-15
Epub
2007-00-21
Pages
699-704
Language
English
Region
England
NLM ID
0266262
PMCID
PMC2375517
Subset
IM
Grants
Medical Research Council · MC_U105178791 · United Kingdom
External Links
PubMed source DOI: 10.1113/jphysiol.2007.136812 PMC Full Text View journal details
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