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PMID: 17589895 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Prognostic significance of HIF-2alpha/EPAS1 expression in hepatocellular carcinoma.

World journal of gastroenterology ·Vol. 13 ·No. 23 ·2007-06-21 ·Pages 3176-82

Bangoura G, Liu ZS, Qian Q, Jiang CQ, Yang GF, Jing S

Abstract

To evaluate the prognostic significance of HIF-2alpha/EPAS1 expression in hepatocellular carcinoma (HCC). Surgical specimens from 315 patients with HCC as well as 196 adjacent noncancerous lesions and 22 cases of normal liver tissue were investigated by immunohistochemistry (IHC) for HIF-2alpha/EPAS1 using a standard detection system. Correlations with clinicopathological factors, VEGF, microvessel density (MVD), and prognosis were analyzed. Immunoreactivity of HIF-2alpha/EPAS1 was positive in 69.5% of HCC, 55.6% of adjacent noncancerous tissue, and 0% of normal liver tissue. And it was significantly correlated with tumor grade, venous invasion, intrahepatic metastasis, necrosis, and capsule infiltration. Correlation analysis of HIF-2alpha/EPAS1 with angiogenic factor VEGF (P<0.001), and MVD (P=0.016) was also noted. HIF-2alpha/EPAS1 protein was less frequently expressed in low MVD cases, whereas a high rate of expression was noted in cases with both medium and high MVD (P=0.042). By Kaplan-Meier analysis, strong HIF-2alpha/EPAS1 staining (>50% of tumor cells) in HCC correlated with a shortened survival in patients (Cox's regression, P<0.001, r=3.699). We conclude that HIF-2alpha/EPAS1 expression may play an important role in tumor progression and prognosis of HCC. Assessment of HIF-2alpha/EPAS1 expression in HCC may be used as a diagnostic tool and possibly a target in the treatment of HCC.

MeSH Terms
Aged Basic Helix-Loop-Helix Transcription Factors/analysis Carcinoma, Hepatocellular/blood supply,chemistry,mortality,pathology Female Humans Immunohistochemistry Liver/chemistry Liver Neoplasms/blood supply,chemistry,mortality,pathology Male Middle Aged Prognosis Vascular Endothelial Growth Factor A/analysis
Chemicals
Basic Helix-Loop-Helix Transcription Factors Vascular Endothelial Growth Factor A endothelial PAS domain-containing protein 1
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Bangoura Gassimou
Department of General Surgery and Liver Cancer Laboratory, Zhong Nan Hospital, Wuhan University School of Medicine, Wuhan 430071, Hubei Province, China.
Liu Zhi-Su
Qian Qun
Jiang Cong-Qing
Yang Gui-Fan
Jing Sun
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Article Info
Journal
World journal of gastroenterology
Abbr.
World J Gastroenterol
ISSN
1007-9327
DOI
10.3748/wjg.v13.i23.3176
Published
2007-06-21
Pages
3176-82
Language
English
Region
United States
NLM ID
100883448
PMCID
PMC4436602
Subset
IM
External Links
PubMed source DOI: 10.3748/wjg.v13.i23.3176 PMC Full Text View journal details
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