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PMID: 17618282 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

A common genetic risk factor for colorectal and prostate cancer.

Nature genetics ·Vol. 39 ·No. 8 ·2007-08-00 ·Pages 954-6

Haiman CA, Le Marchand L, Yamamato J, Stram DO, Sheng X, Kolonel LN, Wu AH, Reich D, Henderson BE

Abstract

Variants on chromosome 8q24 contribute risk for prostate cancer; here, we tested whether they also modulate risk for colorectal cancer. We studied 1,807 affected individuals and 5,511 controls and found that one variant, rs6983267, is also significantly associated with colorectal cancer (odds ratio = 1.22; P = 4.4 x 10(-6)) and that the apportionment of risk among the variants differs significantly between the two cancers. Comprehensive testing in the region uncovered variants capturing significant additional risk. Our results show that variants at 8q24 have different effects on cancer development that depend on the tissue type.

MeSH Terms
Case-Control Studies Chromosomes, Human, Pair 8 Colorectal Neoplasms/genetics Genetic Predisposition to Disease Humans Linkage Disequilibrium Male Polymorphism, Single Nucleotide Prostatic Neoplasms/genetics
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Haiman Christopher A
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA. [email protected]
Le Marchand Loïc
Yamamato Jennifer
Stram Daniel O
Sheng Xin
Kolonel Laurence N
Wu Anna H
Reich David
Henderson Brian E
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Article Info
Journal
Nature genetics
Abbr.
Nat Genet
ISSN
1061-4036
DOI
10.1038/ng2098
Email
[email protected]
Published
2007-08-00
Epub
2007-00-08
Pages
954-6
Language
English
Region
United States
NLM ID
9216904
PMCID
PMC2391283
Subset
IM
Grants
NCI NIH HHS · CA72520 · United States
NCI NIH HHS · CA54281 · United States
NCI NIH HHS · R01 CA072520 · United States
NCI NIH HHS · P01 CA17054 · United States
NCI NIH HHS · CA60987 · United States
NCI NIH HHS · CA63464 · United States
NCI NIH HHS · R01 CA063464-09S1 · United States
NCI NIH HHS · R01 CA063464 · United States
NCI NIH HHS · R01 CA054281 · United States
NCI NIH HHS · U01 CA063464 · United States
NCI NIH HHS · R01 CA060987 · United States
NCI NIH HHS · P01 CA017054 · United States
NCI NIH HHS · R37 CA054281 · United States
External Links
PubMed source DOI: 10.1038/ng2098 PMC Full Text View journal details
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