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PMID: 17653186 Published · ppublish English Journal Article

A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum.

Nature ·Vol. 448 ·No. 7152 ·2007-07-26 ·Pages 435-8

Ploegh HL

Abstract

Lipids are not encoded by a DNA template and therefore cannot be mutated, knocked out or knocked down. This by no means renders them impotent from a cell biological perspective. Here I propose a model for the involvement of lipid rearrangements in the execution of crucial steps in (glyco)protein quality control.

MeSH Terms
Biological Transport Endoplasmic Reticulum/chemistry,metabolism,virology Glycoproteins/chemistry,metabolism Lipid Metabolism Lipids/biosynthesis,chemistry Models, Biological Protein Folding
Chemicals
Glycoproteins Lipids
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Ploegh Hidde L
Whitehead Institute, MIT Department of Biology, Cambridge, Massachusetts 02142, USA. [email protected]
Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature06004
Email
[email protected]
Published
2007-07-26
Pages
435-8
Language
English
Region
England
NLM ID
0410462
Subset
IM
External Links
PubMed source DOI: 10.1038/nature06004 View journal details
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