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PMID: 176597 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Intracellular forms of Epstein-Barr virus DNA in human tumour cells in vivo.

Nature ·Vol. 260 ·No. 5549 ·1976-03-25 ·Pages 302-6

Kaschka-Dierich C, Adams A, Lindahl T, Bornkamm GW, Bjursell G, Klein G, Giovanella BC, Singh S

Abstract

Tumour biopsies from Burkitt lymphoma patients, as well as human nasopharyngeal carcinoma cells growing in athymic mice, contain Epstein-Barr virus DNA as covalently closed circular DNA. In addition integrated viral DNA sequences seem to be present.

MeSH Terms
Burkitt Lymphoma/microbiology Carcinoma/microbiology DNA, Circular Extrachromosomal Inheritance Herpesvirus 4, Human/isolation & purification Humans Nasopharyngeal Neoplasms/microbiology Nucleic Acid Conformation
Chemicals
DNA, Circular
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Kaschka-Dierich C
Adams A
Lindahl T
Bornkamm G W
Bjursell G
Klein G
Giovanella B C
Singh S
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/260302a0
Published
1976-03-25
Pages
302-6
Language
English
Region
England
NLM ID
0410462
Subset
IM
External Links
PubMed source DOI: 10.1038/260302a0 View journal details
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