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PMID: 17671451 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Functional atlas of the integrin adhesome.

Nature cell biology ·Vol. 9 ·No. 8 ·2007-08-00 ·Pages 858-67

Zaidel-Bar R, Itzkovitz S, Ma'ayan A, Iyengar R, Geiger B

Abstract

A detailed depiction of the 'integrin adhesome', consisting of a complex network of 156 components linked together and modified by 690 interactions is presented. Different views of the network reveal several functional 'subnets' that are involved in switching on or off many of the molecular interactions within the network, consequently affecting cell adhesion, migration and cytoskeletal organization. Examination of the adhesome network motifs reveals a relatively small number of key motifs, dominated by three-component complexes in which a scaffolding molecule recruits both a signalling molecule and its downstream target. We discuss the role of the different network modules in regulating the structural and signalling functions of cell-matrix adhesions.

MeSH Terms
Animals Cell Adhesion/physiology Cell-Matrix Junctions/physiology Cytoskeleton/metabolism Databases, Factual Integrins/genetics,metabolism Signal Transduction/physiology
Chemicals
Integrins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Zaidel-Bar Ronen
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel.
Itzkovitz Shalev
Ma'ayan Avi
Iyengar Ravi
Geiger Benjamin
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Article Info
Journal
Nature cell biology
Abbr.
Nat Cell Biol
ISSN
1465-7392
DOI
10.1038/ncb0807-858
Published
2007-08-00
Pages
858-67
Language
English
Region
England
NLM ID
100890575
PMCID
PMC2735470
Subset
IM
Grants
NEI NIH HHS · PN2 EY016586 · United States
NIGMS NIH HHS · P50 GM071558 · United States
NIGMS NIH HHS · U54 GM064346 · United States
NIGMS NIH HHS · GM-54508 · United States
NIGMS NIH HHS · P50 GM071558-020007 · United States
NIGMS NIH HHS · P50 GM071558-030007 · United States
NIGMS NIH HHS · P50 GM071558-01A20007 · United States
NIGMS NIH HHS · U54 GM64346 · United States
NEI NIH HHS · PN2 EY016586-05 · United States
NIGMS NIH HHS · R01 GM054508 · United States
NIGMS NIH HHS · R01 GM054508-20 · United States
External Links
PubMed source DOI: 10.1038/ncb0807-858 PMC Full Text View journal details
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