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PMID: 17680327 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Distribution of HBV genotypes, subgenotypes and HBsAg subtypes among chronically infected patients in Serbia.

Archives of virology ·Vol. 152 ·No. 11 ·2007-00-00 ·Pages 2017-25

Lazarevic I, Cupic M, Delic D, Svirtlih NS, Simonovic J, Jovanovic T

Abstract

Hepatitis B virus (HBV) has been classified into eight genotypes (some of them further divided into two or more subgenotypes) and nine HBsAg subtypes, distinctly distributed geographically. The aim of this study was to gain insight into the distribution of HBV genotypes, subgenotypes and HBsAg subtypes among HBV chronically infected patients in Serbia, since there were no previously published data on this subject. Eighty-nine plasma samples that gave a positive result in a nested PCR were included for genotype identification. Genotyping was performed by direct sequencing of the part of the S/pol gene, and the HBsAg subtype was deduced from the HBsAg sequence. Two HBV genotypes, A and D, were encountered in Serbia, with genotype D (D - 82%, A - 18%) and subgenotype D3 (47.9%) being prevalent. Genotype D isolates had three assigned subtypes (ayw2, ayw3, ayw4), with ayw2 found to be the most prevalent (ayw2 - 53.4%, ayw3 - 43.8%, ayw4 - 1.4%). Genotype A isolates belonged to the A2 subgenotype and the HBsAg subtype adw2, as expected for samples from European population. The results correspond to country's geographical position, being in close proximity to the Mediterranean basin and on the main route between the Middle East and Central Europe.

MeSH Terms

Adolescent Adult Aged Female Genotype Hepatitis B Surface Antigens/blood,classification,genetics Hepatitis B virus/classification,genetics,isolation & purification Hepatitis B, Chronic/epidemiology,virology Humans Male Middle Aged Molecular Sequence Data Phylogeny Sequence Analysis, DNA Yugoslavia/epidemiology

Chemicals

Hepatitis B Surface Antigens

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Lazarevic I

School of Medicine, Institute of Microbiology and Immunology, University of Belgrade, Belgrade, Serbia. [email protected]

Cupic M

Delic D

Svirtlih N S

Simonovic J

Jovanovic T

Article Info

Journal

Archives of virology

Abbr.

Arch Virol

ISSN

0304-8608

DOI

10.1007/s00705-007-1031-0

[email protected]

Published

2007-00-00

Epub

2007-00-06

Pages

2017-25

Language

English

Region

Austria

NLM ID

7506870

Subset

Databases

GENBANK

EF177853, EF177854, EF177855, EF177856, EF177857, EF177858, EF177859, EF177860, EF177861, EF177862, EF177863, EF177864, EF177865, EF177866, EF177867, EF177868, EF177869, EF177870, EF177871, EF177872, EF177873, EF177874, EF177875, EF177876, EF177877, EF177878, EF177879, EF177880, EF177881, EF177882, EF177883, EF177884, EF177885, EF177886, EF177887, EF177888, EF177889, EF177890, EF177891, EF177892, EF177893, EF177894, EF177895, EF177896, EF177897, EF177898, EF177899, EF177900, EF177901, EF177902, EF177903, EF177904, EF177905, EF177906, EF177907, EF177908, EF177909, EF177910, EF177911, EF177912, EF177913, EF177914, EF177915, EF177916, EF177917, EF177918, EF177919, EF177920, EF177921, EF177922, EF177923, EF177924, EF177925, EF177926, EF177927, EF177928, EF177929, EF177930, EF177931, EF177932, EF177933, EF177934, EF177935, EF177936, EF177937, EF177938, EF177939, EF177940, EF177941

External Links

PubMed source DOI: 10.1007/s00705-007-1031-0 View journal details

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Distribution of HBV genotypes, subgenotypes and HBsAg subtypes among chronically infected patients in Serbia.

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