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PMID: 17681762 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

A detailed examination of cytokine abnormalities in Major Depressive Disorder.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology ·Vol. 18 ·No. 3 ·2008-03-00 ·Pages 230-3

Simon NM, McNamara K, Chow CW, Maser RS, Papakostas GI, Pollack MH, Nierenberg AA, Fava M, Wong KK

Abstract

Recent technological advances offer an opportunity to further elucidate the complex cytokine network in Major Depressive Disorder (MDD). Twenty cytokines were simultaneously assessed in 49 individuals with MDD and 49 age and gender matched controls. Multiple pro-inflammatory and two anti-inflammatory cytokines were significantly elevated in the MDD sample, including an antidepressant naïve subset. These data support a generalized chronic inflammatory state in MDD, and implicate additional cytokines and chemokines previously linked to cardiovascular disease.

MeSH Terms
Adult Chemokines/metabolism Cytokines/metabolism Depressive Disorder, Major/metabolism Female Humans Male Middle Aged Psychiatric Status Rating Scales Reference Values Sex Characteristics
Chemicals
Chemokines Cytokines
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Simon N M
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. [email protected]
McNamara K
Chow C W
Maser R S
Papakostas G I
Pollack M H
Nierenberg A A
Fava M
Wong K K
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Article Info
Journal
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Abbr.
Eur Neuropsychopharmacol
ISSN
0924-977X
DOI
10.1016/j.euroneuro.2007.06.004
Email
[email protected]
Published
2008-03-00
Epub
2007-00-03
Pages
230-3
Language
English
Region
Netherlands
NLM ID
9111390
PMCID
PMC2267745
Subset
IM
Grants
NIMH NIH HHS · R10 MH056057-03 · United States
NIMH NIH HHS · R10 MH56058 · United States
External Links
PubMed source DOI: 10.1016/j.euroneuro.2007.06.004 PMC Full Text View journal details
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