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PMID: 17683974 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

How cells respond to interferons revisited: from early history to current complexity.

Cytokine & growth factor reviews ·Vol. 18 ·No. 5-6 ·2007-00-00 ·Pages 419-23

Stark GR

Abstract

A brief account of how I became involved in interferon research is followed by recollections of key experiments that led to the discovery of the roles of the JAKs and STATs in interferon-dependent signaling. I then outline the complex responses of cells to interferons, including the roles of kinases other than JAKs and transcription factors other than STATs, differential responses to interferons alpha and beta, modulation of response by prior exposure to other cytokines ("priming"), cytokine-dependent induction of high level expression of STATs 1 and 3 and the activation of a new set of genes by these unphosphorylated STATs, and diverse patterns of STAT activation in different cell types in response to a single interferon.

MeSH Terms
Gene Expression Humans Interferons/metabolism Janus Kinases/metabolism STAT Transcription Factors/metabolism
Chemicals
STAT Transcription Factors Interferons Janus Kinases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Stark George R
Department of Molecular Genetics, Cleveland Clinic, Cleveland OH 44195, United States. [email protected]
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22 references, click to expand
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Article Info
Journal
Cytokine & growth factor reviews
Abbr.
Cytokine Growth Factor Rev
ISSN
1359-6101
DOI
10.1016/j.cytogfr.2007.06.013
Email
[email protected]
Published
2007-00-00
Epub
2007-00-01
Pages
419-23
Language
English
Region
England
NLM ID
9612306
PMCID
PMC2081984
Subset
IM
Grants
NCI NIH HHS · P01 CA062220 · United States
NCI NIH HHS · P01 CA062220-13 · United States
NCI NIH HHS · P01 CA62220 · United States
External Links
PubMed source DOI: 10.1016/j.cytogfr.2007.06.013 PMC Full Text View journal details
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