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PMID: 176958 Published · ppublish English Journal Article

Activation of human leucocyte procollagenase by rheumatoid synovial tissue culture medium.

Annals of the rheumatic diseases ·Vol. 34 ·No. 6 ·1975-12-00 ·Pages 520-3

Wize J, Abgarowicz T, Wojtecka-Lukasik E, Ksiezny S, Dancewicz AM

Abstract

Production of a factor activating leucocyte procollagenase by tissue culture of rheumatoid synovium was shown. The activator was isolated, partly purified, and shown to be thermolabile, nondialysable, and had no activity toward casein, haemoglobin, histones, and PZ-peptide. The activity of the activator was partly decreased by trypsin.

MeSH Terms
Arthritis, Rheumatoid/enzymology Culture Techniques Enzyme Precursors/metabolism Humans Microbial Collagenase/metabolism Synovial Fluid/enzymology Viscosity
Chemicals
Enzyme Precursors Microbial Collagenase
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Wize J
Abgarowicz T
Wojtecka-Lukasik E
Ksiezny S
Dancewicz A M
References (14)
14 references, click to expand
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Article Info
Journal
Annals of the rheumatic diseases
Abbr.
Ann Rheum Dis
ISSN
0003-4967
DOI
10.1136/ard.34.6.520
Published
1975-12-00
Pages
520-3
Language
English
Region
England
NLM ID
0372355
PMCID
PMC1006474
Subset
IM
External Links
PubMed source DOI: 10.1136/ard.34.6.520 PMC Full Text View journal details
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