Home LiteratureArticle Details
PMID: 17702561 Published · ppublish English Journal Article Review

Alternatively activated macrophages in helminth infections.

Current opinion in immunology ·Vol. 19 ·No. 4 ·2007-08-00 ·Pages 448-53

Kreider T, Anthony RM, Urban JF, Gause WC

Abstract

Helminthic parasites can trigger highly polarized immune responses typically associated with increased numbers of CD4(+) Th2 cells, eosinophils, mast cells, and basophils. These cell populations are thought to coordinate an effective response ultimately leading to parasite expulsion, but they also play a role in the regulation of associated pathologic inflammation. Recent studies suggest that macrophages, conventionally associated with IFN-gamma-dominant Th1-type responses to many bacteria and viruses, also play an essential role in the Th2-type inflammatory response. These macrophages are referred to as alternatively activated macrophages (AAMPhis) as they express a characteristic pattern of cell surface and secreted molecules distinct from that of classically activated macrophages (CAMPhis) associated with microbe infections. In this review, we will discuss recent findings regarding the role of AAMPhis in the development of disease and host protection following helminth infection.

MeSH Terms
Animals Antigen-Presenting Cells/immunology,metabolism Antigens, Helminth/immunology,metabolism CD4-Positive T-Lymphocytes/immunology,metabolism Cytokines/immunology,metabolism Helminthiasis/immunology,parasitology Helminths/immunology,physiology Humans Inflammation Mediators/immunology,metabolism Macrophage Activation Macrophages/immunology Th1 Cells/immunology,metabolism Th2 Cells/immunology,metabolism Wound Healing/immunology
Chemicals
Antigens, Helminth Cytokines Inflammation Mediators
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Kreider Timothy
Department of Medicine, UMDNJ - New Jersey Medical School, MSB 639, 185 South Orange Avenue, Newark, NJ 07103, USA.
Anthony Robert M
Urban Joseph F
Gause William C
References (47)
47 references, click to expand
  1. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.
    Trends Immunol. 2002 Nov;23(11):549-55 PMID: 12401408
  2. Chronic helminth infection induces alternatively activated macrophages expressing high levels of CCR5 with low interleukin-12 production and Th2-biasing ability.
    Infect Immun. 2002 Jul;70(7):3656-64 PMID: 12065507
  3. The immune response to parasitic helminths: insights from murine models.
    Trends Immunol. 2003 May;24(5):269-77 PMID: 12738422
  4. Disruption of the ICOS-B7RP-1 costimulatory pathway leads to enhanced hepatic immunopathology and increased gamma interferon production by CD4 T cells in murine schistosomiasis.
    Infect Immun. 2003 Jul;71(7):4040-4 PMID: 12819093
  5. Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair.
    J Immunol. 2003 Oct 1;171(7):3655-67 PMID: 14500663
  6. Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses.
    Eur J Immunol. 2003 Oct;33(10):2706-16 PMID: 14515254
  7. IL-10 induces gene expression in macrophages: partial overlap with IL-5 but not with IL-4 induced genes.
    Cytokine. 2003 Oct;24(1-2):46-56 PMID: 14561490
  8. FIZZ1 stimulation of myofibroblast differentiation.
    Am J Pathol. 2004 Apr;164(4):1315-26 PMID: 15039219
  9. Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology.
    Immunity. 2004 May;20(5):623-35 PMID: 15142530
  10. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation.
    Science. 2004 Jun 11;304(5677):1678-82 PMID: 15192232
  11. Schistosoma mansoni worms induce anergy of T cells via selective up-regulation of programmed death ligand 1 on macrophages.
    J Immunol. 2004 Jul 15;173(2):1240-8 PMID: 15240716
  12. Requirements for the development of IL-4-producing T cells during intestinal nematode infections: what it takes to make a Th2 cell in vivo.
    Immunol Rev. 2004 Oct;201:57-74 PMID: 15361233
  13. Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites.
    Immunol Rev. 2004 Oct;201:139-55 PMID: 15361238
  14. A non-classical type of alveolar macrophage response to Trichinella spiralis infection.
    Parasite Immunol. 2004 Apr;26(4):197-205 PMID: 15367297
  15. Effects of blocking B7-1 and B7-2 interactions during a type 2 in vivo immune response.
    J Immunol. 1997 May 1;158(9):4088-96 PMID: 9126967
  16. Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses.
    Curr Biol. 1998 May 21;8(11):669-72 PMID: 9635196
  17. The chemokine system in diverse forms of macrophage activation and polarization.
    Trends Immunol. 2004 Dec;25(12):677-86 PMID: 15530839
  18. Thioredoxin peroxidase secreted by Fasciola hepatica induces the alternative activation of macrophages.
    Infect Immun. 2005 Jan;73(1):166-73 PMID: 15618151
  19. Chitinase and Fizz family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells.
    Infect Immun. 2005 Jan;73(1):385-94 PMID: 15618176
  20. Interleukin-4 and dexamethasone counterregulate extracellular matrix remodelling and phagocytosis in type-2 macrophages.
    Scand J Immunol. 2005 Jan;61(1):10-7 PMID: 15644118
  21. Anti-inflammatory activity of PAS-1, a protein component of Ascaris suum.
    Inflamm Res. 2005 Jan;54(1):17-21 PMID: 15723200
  22. Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation.
    J Leukoc Biol. 2005 Mar;77(3):321-7 PMID: 15591125
  23. Reactive oxygen species and 12/15-lipoxygenase contribute to the antiproliferative capacity of alternatively activated myeloid cells elicited during helminth infection.
    J Immunol. 2005 May 15;174(10):6095-104 PMID: 15879104
  24. Role of the programmed Death-1 pathway in the suppressive activity of alternatively activated macrophages in experimental cysticercosis.
    Int J Parasitol. 2005 Nov;35(13):1349-58 PMID: 16126211
  25. Inflammatory cells during wound repair: the good, the bad and the ugly.
    Trends Cell Biol. 2005 Nov;15(11):599-607 PMID: 16202600
  26. Helper T cell differentiation enters a new era: le roi est mort; vive le roi!
    J Exp Med. 2006 Apr 17;203(4):809-12 PMID: 16606679
  27. F4/80+ alternatively activated macrophages control CD4+ T cell hyporesponsiveness at sites peripheral to filarial infection.
    J Immunol. 2006 Jun 1;176(11):6918-27 PMID: 16709852
  28. The IL-21 receptor augments Th2 effector function and alternative macrophage activation.
    J Clin Invest. 2006 Jul;116(7):2044-55 PMID: 16778988
  29. Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites.
    Nat Med. 2006 Aug;12(8):955-60 PMID: 16892038
  30. Alternatively activated macrophages express the IL-27 receptor alpha chain WSX-1.
    Immunobiology. 2006;211(6-8):427-36 PMID: 16920482
  31. Innate immune responses to lung-stage helminth infection induce alternatively activated alveolar macrophages.
    Infect Immun. 2006 Sep;74(9):4970-81 PMID: 16926388
  32. Biochemical and functional characterization of three activated macrophage populations.
    J Leukoc Biol. 2006 Dec;80(6):1298-307 PMID: 16905575
  33. Acute cysticercosis favours rapid and more severe lesions caused by Leishmania major and Leishmania mexicana infection, a role for alternatively activated macrophages.
    Cell Immunol. 2006 Aug;242(2):61-71 PMID: 17118349
  34. Induction of IL-4 expression in CD4(+) T cells by thymic stromal lymphopoietin.
    J Immunol. 2007 Feb 1;178(3):1396-404 PMID: 17237387
  35. IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo.
    Blood. 2007 Mar 1;109(5):2023-31 PMID: 17077330
  36. Chitin induces accumulation in tissue of innate immune cells associated with allergy.
    Nature. 2007 May 3;447(7140):92-6 PMID: 17450126
  37. Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages.
    J Leukoc Biol. 2007 Jun;81(6):1434-44 PMID: 17339609
  38. Kupffer cells from Schistosoma mansoni-infected mice participate in the prompt type 2 differentiation of hepatic T cells in response to worm antigens.
    J Immunol. 1999 Dec 15;163(12):6702-11 PMID: 10586067
  39. Identification of a novel eosinophil chemotactic cytokine (ECF-L) as a chitinase family protein.
    J Biol Chem. 2000 Jan 14;275(2):1279-86 PMID: 10625674
  40. IL-13-mediated worm expulsion is B7 independent and IFN-gamma sensitive.
    J Immunol. 2000 Apr 15;164(8):4250-6 PMID: 10754322
  41. NOS-2 mediates the protective anti-inflammatory and antifibrotic effects of the Th1-inducing adjuvant, IL-12, in a Th2 model of granulomatous disease.
    Am J Pathol. 2000 Sep;157(3):945-55 PMID: 10980133
  42. CTLA-4 regulates induction of anergy in vivo.
    Immunity. 2001 Feb;14(2):145-55 PMID: 11239447
  43. Alternatively activated macrophages differentially express fibronectin and its splice variants and the extracellular matrix protein betaIG-H3.
    Scand J Immunol. 2001 Apr;53(4):386-92 PMID: 11285119
  44. A schistosome-expressed immunomodulatory glycoconjugate expands peritoneal Gr1(+) macrophages that suppress naive CD4(+) T cell proliferation via an IFN-gamma and nitric oxide-dependent mechanism.
    J Immunol. 2001 Oct 15;167(8):4293-302 PMID: 11591752
  45. Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism.
    J Immunol. 2001 Dec 1;167(11):6533-44 PMID: 11714822
  46. Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages.
    J Leukoc Biol. 2002 Apr;71(4):597-602 PMID: 11927645
  47. Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro.
    Immunol Lett. 2003 Jan 22;85(2):173-80 PMID: 12527225
Article Info
Journal
Current opinion in immunology
Abbr.
Curr Opin Immunol
ISSN
0952-7915
DOI
10.1016/j.coi.2007.07.002
Published
2007-08-00
Epub
2007-00-16
Pages
448-53
Language
English
Region
England
NLM ID
8900118
PMCID
PMC2000338
Subset
IM
Grants
NIAID NIH HHS · R01 AI031678 · United States
NIAID NIH HHS · R01 AI066188-02 · United States
NIAID NIH HHS · R01 AI066188-01A1 · United States
NIAID NIH HHS · R01 AI031678-13 · United States
NIAID NIH HHS · R01 AI031678-14 · United States
NIAID NIH HHS · R01 AI066188 · United States
External Links
PubMed source DOI: 10.1016/j.coi.2007.07.002 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2