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PMID: 17703304 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

NALP inflammasomes: a central role in innate immunity.

Seminars in immunopathology ·Vol. 29 ·No. 3 ·2007-09-00 ·Pages 213-29

Martinon F, Gaide O, Pétrilli V, Mayor A, Tschopp J

Abstract

Inflammasomes are cytoplasmic multiprotein complexes that mediate the maturation of the proinflammatory cytokines interleukin-1beta (IL-1beta), IL-18, and possibly IL-33 by controlling the activation of the inflammatory caspases-1 and -5. Assembly of inflammasomes depends on NOD-like receptor (NLR) family members such as NALPs, NAIP, and IPAF. Various microbial and endogenous stimuli activate different types of inflammasomes. This article focuses on the Pyrin domain containing NLRs, known as NALP proteins. Recent findings provide exciting insights into how these proteins might be activated and also provide evidence of the critical role of the NALP inflammasomes in innate immunity and inflammatory diseases.

MeSH Terms
Adaptor Proteins, Signal Transducing/immunology,metabolism Animals Cytokines/immunology,metabolism Cytoplasm/immunology,metabolism Humans Immunity, Innate Inflammation/immunology,metabolism Models, Immunological Multiprotein Complexes/immunology,metabolism
Chemicals
Adaptor Proteins, Signal Transducing Cytokines Multiprotein Complexes
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Martinon Fabio
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA. [email protected]
Gaide Olivier
Pétrilli Virgine
Mayor Annick
Tschopp Jürg
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Article Info
Journal
Seminars in immunopathology
Abbr.
Semin Immunopathol
ISSN
1863-2297
DOI
10.1007/s00281-007-0079-y
Email
[email protected]
Published
2007-09-00
Epub
2007-00-17
Pages
213-29
Language
English
Region
Germany
NLM ID
101308769
Subset
IM
External Links
PubMed source DOI: 10.1007/s00281-007-0079-y View journal details
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