Abstract
Over 20 years ago, Watson described three families with a condition characterised by pulmonary valvular stenosis, café au lait patches, and dull intelligence. Short stature is an additional feature of this autosomal dominant condition. A fourth family with Watson syndrome has since been reported. We have had the opportunity to review members of three of these four families. The clinical phenotype of Watson syndrome has been expanded to include relative macrocephaly and Lisch nodules in the majority of affected subjects, and neurofibromas in one-third of family members. Because the additional clinical findings enhance the similarity between Watson syndrome and neurofibromatosis 1, molecular linkage studies have been performed using probes flanking the NF1 gene on chromosome 17. Probe HHH202 showed the tightest linkage to Watson syndrome with a maximum lod score of 3.59 at phi = 0.0 (95% confidence limits of phi = 0.0-0.15). This suggests either that Watson syndrome and neurofibromatosis 1 are allelic, or that there is a series of contiguous genes for pulmonary stenosis, neurocutaneous anomalies, short stature, and mental retardation on 17q.
MeSH Terms
Chromosomes, Human, Pair 17
Female
Genetic Linkage
Growth Disorders/genetics
Humans
Intellectual Disability/genetics
Male
Neurofibromatosis 1/classification,genetics
Pedigree
Pigmentation Disorders/genetics
Pulmonary Valve Stenosis/genetics
Syndrome
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Allanson J E
Division of Genetics, Children's Hospital of Eastern Ontario, Canada.
Upadhyaya M
Watson G H
Partington M
MacKenzie A
Lahey D
MacLeod H
Sarfarazi M
Broadhead W
Harper P S
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