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PMID: 17712533 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

Mechanisms of tumor growth and metastasis in head and neck squamous cell carcinoma.

Current treatment options in oncology ·Vol. 8 ·No. 3 ·2007-06-00 ·Pages 227-38

Walsh JE, Lathers DM, Chi AC, Gillespie MB, Day TA, Young MR

Abstract

The formation and progression of head and neck squamous cell carcinoma (HNSCC) is multisystemic and involves the immune system, vascularization, and dissemination. Immune involvement includes the subversion of anti-tumor defenses. Vascularization involves both angiogenesis and vasculogenesis. Dissemination involves local tumor invasion as well as distant metastasis through processes including angiogenesis and lymphangiogenesis. Current studies in the dysregulation of various processes, including genetic stability, angiogenesis, lymphangiogenesis, immune regulation, and immune function, are opening opportunities for the development of targeted tumor therapies. The interrelationship of these processes in HNSCC development will be explored in this review.

MeSH Terms
Animals Carcinoma, Squamous Cell/blood supply,pathology,secondary Disease Progression Head and Neck Neoplasms/blood supply,pathology Humans Neoplasm Metastasis Neovascularization, Pathologic/pathology
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Walsh Jarrett E
Research Service, Ralph H. Johnson VA Medical Center, 109 Bee Street, Charleston, SC 29401-5799, USA.
Lathers Deanne M R
Chi Angela C
Gillespie M Boyd
Day Terry A
Young M Rita I
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Article Info
Journal
Current treatment options in oncology
Abbr.
Curr Treat Options Oncol
ISSN
1527-2729
DOI
10.1007/s11864-007-0032-2
Published
2007-06-00
Pages
227-38
Language
English
Region
United States
NLM ID
100900946
Subset
IM
Grants
NCI NIH HHS · CA85266 · United States
NCI NIH HHS · CA97813 · United States
External Links
PubMed source DOI: 10.1007/s11864-007-0032-2 View journal details
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