The structure and function of MHC molecules. Possible implications for the control of tumor growth by MHC-restricted T cells.

Seminars in cancer biology ·Vol. 2 ·No. 5 ·1991-10-00 ·Pages 275-82

Kourilsky P, Jaulin C, Ley V

Abstract

We briefly survey recent basic progress on the structure and function of MHC molecules. We call attention on a number of remaining unanswered questions, and focus on a few points which we think might be of importance in immune surveillance against tumors mediated by MHC restricted T cells. In particular, we discuss the possible peptidic nature of certain tumor antigens. Following these lines, we mention a recent approach for the in vivo activation of specific CTL.

MeSH Terms

Animals Antigen-Presenting Cells/immunology Antigens, Neoplasm/immunology,metabolism HLA Antigens/immunology,metabolism Histocompatibility Antigens/immunology,metabolism Humans Immune Tolerance Immunologic Surveillance Immunotherapy Models, Biological Neoplasms/immunology,therapy Neoplasms, Experimental/immunology Peptide Fragments/immunology Protein Conformation Receptors, Antigen, T-Cell/immunology T-Lymphocytes, Cytotoxic/immunology

Chemicals

Antigens, Neoplasm HLA Antigens Histocompatibility Antigens Peptide Fragments Receptors, Antigen, T-Cell

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Kourilsky P

Unité de Biologie Moléculaire du Gène, U. 277 INSERM-U.A.C. 535 CNRS, Institut Pasteur, France.

Jaulin C

Ley V

Article Info

Journal

Seminars in cancer biology

Abbr.

Semin Cancer Biol

ISSN

1044-579X

Published

1991-10-00

Pages

275-82

Language

English

Region

England

NLM ID

9010218

Subset

External Links

PubMed source View journal details

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The structure and function of MHC molecules. Possible implications for the control of tumor growth by MHC-restricted T cells.

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