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PMID: 17766060 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Familial transmission of derived phenotypes for molecular genetic studies of substance use disorders.

Drug and alcohol dependence ·Vol. 92 ·No. 1-3 ·2008-01-01 ·Pages 100-7

Faraone SV, Adamson JJ, Wilens TE, Monuteaux MC, Biederman J

Abstract

Although family, twin, and adoption studies indicate that genes play a significant etiologic role in the development of substance use disorders (SUDs), detecting specific genes has been difficult due to uncertainties about how to define SUDs, genetic heterogeneity and variable phenotypic expression of SUD genotypes. We used data from families recruited into six contemporaneous studies of children and adults to derive candidate SUD phenotypes using principle factors factor analysis with varimax rotation. We previously found evidence of two SUD phenotypes in offspring: a psychopathology dimension and a cognitive impairment dimension. We found evidence for one SUD-related phenotype in adults that we term Psychopathology and Cognitive Impairment. Parental factor scores significantly predicted both offspring phenotypes, as well as parental SUD (OR=1.41, p<0.001) and offspring SUD (mother's phenotype: OR=1.34, p=0.04; father's phenotype: OR=1.33, p=0.01). Offspring phenotype predicted offspring SUD (psychopathology phenotype: OR=2.96, p<0.001; cognitive impairment: OR=1.33, p=0.04); in offspring, baseline psychopathology predicted SUD at follow-up assessments (OR=1.55, p=0.01). Results suggest that these candidate SUD phenotypes may be useful for genetic studies of SUD.

MeSH Terms
Adult Attention Deficit Disorder with Hyperactivity/genetics Bipolar Disorder/genetics Cognition Disorders/complications,psychology Depressive Disorder/genetics Factor Analysis, Statistical Family Female Humans Male Middle Aged Neuropsychological Tests Panic Disorder/genetics Parents Phenotype Predictive Value of Tests Psychiatric Status Rating Scales Psychomotor Performance Substance-Related Disorders/genetics,psychology Wechsler Scales
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Faraone Stephen V
Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams St., Syracuse, NY 13210, USA. [email protected]
Adamson Joel J
Wilens Timothy E
Monuteaux Michael C
Biederman Joseph
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Article Info
Journal
Drug and alcohol dependence
Abbr.
Drug Alcohol Depend
ISSN
0376-8716
DOI
10.1016/j.drugalcdep.2007.07.002
Email
[email protected]
Published
2008-01-01
Epub
2007-00-04
Pages
100-7
Language
English
Region
Ireland
NLM ID
7513587
PMCID
PMC2273999
Subset
IM
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NIMH NIH HHS · R21 MH066191-01 · United States
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NICHD NIH HHS · R01 HD037999 · United States
NIMH NIH HHS · R21 MH066191-02 · United States
NIMH NIH HHS · R13 MH059126-04 · United States
NIMH NIH HHS · R01 MH062873-03 · United States
NICHD NIH HHS · R01 HD037694-04 · United States
NICHD NIH HHS · R01 HD037999-03 · United States
NIMH NIH HHS · R01 MH062873-05S1 · United States
NIMH NIH HHS · R13 MH059126-05 · United States
NIMH NIH HHS · R21 MH066191 · United States
NIMH NIH HHS · R01 MH081803-01 · United States
NIMH NIH HHS · R13 MH059126 · United States
NIMH NIH HHS · R13 MH059126-01 · United States
NIMH NIH HHS · R01 MH057934 · United States
NIMH NIH HHS · R21 MH066191-04 · United States
NICHD NIH HHS · R01 HD037694-02 · United States
NIMH NIH HHS · R01 MH081803 · United States
NIMH NIH HHS · R01 MH066877-03 · United States
NIMH NIH HHS · R21 MH066191-03 · United States
NIMH NIH HHS · R13 MH059126-06A1 · United States
NIDA NIH HHS · R01 DA018659 · United States
NICHD NIH HHS · R01 HD037694-01 · United States
NIMH NIH HHS · R01 MH062873-05 · United States
NICHD NIH HHS · R01 HD037694 · United States
NICHD NIH HHS · R01 HD037999-02 · United States
NIMH NIH HHS · R01 MH066877-05A1 · United States
NIMH NIH HHS · R01 MH066877-06 · United States
NICHD NIH HHS · R01 HD037999-04 · United States
NIDA NIH HHS · R01 DA018659-01 · United States
NICHD NIH HHS · R01 HD037999-05 · United States
NIMH NIH HHS · R01 MH062873-01A1 · United States
NIMH NIH HHS · R01 MH062873-02 · United States
NIMH NIH HHS · R13 MH059126-03S1 · United States
NIMH NIH HHS · R13 MH059126-08 · United States
NIDA NIH HHS · R01 DA018659-02 · United States
NICHD NIH HHS · R01 HD037999-01 · United States
NIDA NIH HHS · R01 DA018659-03 · United States
NIMH NIH HHS · R01 MH057934-03 · United States
NICHD NIH HHS · R01 HD037694-05 · United States
NIMH NIH HHS · R01MH57934 · United States
NIMH NIH HHS · R01 MH057934-02 · United States
NIMH NIH HHS · R13 MH059126-03 · United States
NIMH NIH HHS · R01 MH062873-04 · United States
NIMH NIH HHS · R01 MH066877-02 · United States
External Links
PubMed source DOI: 10.1016/j.drugalcdep.2007.07.002 PMC Full Text View journal details
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