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PMID: 177856 Published · ppublish English Journal Article Review

Protein-liposome interactions and their relevance to the structure and function of cell membranes.

Molecular and cellular biochemistry ·Vol. 10 ·No. 3 ·1976-02-25 ·Pages 171-90

Kimelberg HK

Abstract

Recent studies on the interactions of soluble proteins, membrane proteins and enzymes with phospholipid model membranes are reviewed. Similarities between the properties of such systems and the behavior of biomembranes, such as alterations in the redox potential of cytochrome c after binding to membranes and effects of phospholipid fluidity on (Na+K) ATPase activity, are emphasized. The degree of correspondence between the behavior of model systems and natural membranes encourages the continuing use of model membranes in studies on protein-lipid interactions. However, some of the data on the increase of surface pressure of phospholipid monolayers by proteins and increases in the permeability of liposomes indicate that many soluble proteins also have a capability to interact hydrophobically with phospholipids. Thus a sharp distinction between both peripheral and integral membrane proteins and non-membrane proteins are not seen by these techniques. Cautious use of such studies, however, should lead to greater understanding of the molecular basis of cell membrane structure and function in normal and pathological states. Studies implicating protein-lipid interactions and (Na+K) ATPase activity in membrane alterations in disease states are also briefly discussed.

MeSH Terms
Adenosine Triphosphatases/metabolism Animals Binding Sites Cell Membrane/physiology,ultrastructure Cytochrome c Group Enzyme Activation/drug effects Hemoglobins Kinetics Lipoproteins Liposomes Membranes, Artificial Microscopy, Electron Models, Biological Molecular Conformation Permeability Phospholipids/pharmacology Potassium/pharmacology Protein Binding Protein Conformation Proteins Sodium/pharmacology Thermodynamics
Chemicals
Cytochrome c Group Hemoglobins Lipoproteins Liposomes Membranes, Artificial Phospholipids Proteins Sodium Adenosine Triphosphatases Potassium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kimelberg H K
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Article Info
Journal
Molecular and cellular biochemistry
Abbr.
Mol Cell Biochem
ISSN
0300-8177
DOI
10.1007/BF01731688
Published
1976-02-25
Pages
171-90
Language
English
Region
Netherlands
NLM ID
0364456
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01731688 View journal details
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