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PMID: 17822959 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Chromatin remodeling and cancer, Part II: ATP-dependent chromatin remodeling.

Trends in molecular medicine ·Vol. 13 ·No. 9 ·2007-09-00 ·Pages 373-80

Wang GG, Allis CD, Chi P

Abstract

Connections between perturbations that lie outside of our genome, that is, epigenetic alternations, and tumorigenesis have become increasingly apparent. Dynamic chromatin remodeling of the fundamental nucleosomal structure (covered in this review) or the covalent marks residing in the histone proteins that make up this structure (covered previously in part I) underlie many fundamental cellular processes, including transcriptional regulation and DNA-damage repair. Dysregulation of these processes has been linked to cancer development. Mechanisms of chromatin remodeling include dynamic interplay between ATP-dependent complexes, covalent histone modifications, utilization of histone variants and DNA methylation. In part II of this series, we focus on connections between ATP-dependent chromatin-remodeling complexes and oncogenesis and discuss the potential clinical implications of chromatin remodeling and cancer.

MeSH Terms
Adenosine Triphosphate/metabolism,physiology Animals Chromatin/metabolism,physiology Histones/chemistry,metabolism Humans Models, Biological Neoplasms/metabolism,physiopathology Protein Processing, Post-Translational
Chemicals
Chromatin Histones Adenosine Triphosphate
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Wang Gang G
Laboratory of Chromatin Biology, The Rockefeller University, and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Allis C David
Chi Ping
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Article Info
Journal
Trends in molecular medicine
Abbr.
Trends Mol Med
ISSN
1471-4914
DOI
10.1016/j.molmed.2007.07.004
Published
2007-09-00
Epub
2007-00-05
Pages
373-80
Language
English
Region
England
NLM ID
100966035
PMCID
PMC4337864
Subset
IM
Grants
NIGMS NIH HHS · R01 GM040922 · United States
NCI NIH HHS · T32 CA009207 · United States
NCI NIH HHS · 5T32CA009207-28 · United States
External Links
PubMed source DOI: 10.1016/j.molmed.2007.07.004 PMC Full Text View journal details
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