Abstract
Fracture healing in long bones is a sequential multistep cascade of hemostasis, transient inflammation, chemotaxis of progenitor cells, mitosis, differentiation of cartilage, and replacement with bone. This multistep cascade is orchestrated by cytokines and morphogens. Members of the interleukin (IL)-17 family, including IL-17B, have been identified in cartilage, but their expression during fracture healing is unknown. In this study, we determined the immunolocalization of cytokines IL-17A and IL-17B, along with the IL-17 receptor (IL-17R) and IL-17 receptor-like protein (IL-17RL), during the sequence of fracture repair in a standard model. The results were extended to developmental changes in the epiphyseal growth plate of long bones. Members of the IL-17 family were localized in chondrocytes in the fracture callus. Moreover, we found significant parallels to the localization of these cytokines and their receptors in chondrocytes during an endochondral differentiation program in the epiphyseal growth plate.
MeSH Terms
Animals
Animals, Newborn
Bony Callus/metabolism
Cell Differentiation
Chondrocytes/cytology,metabolism
Femoral Fractures/metabolism
Fracture Healing
Growth Plate/growth & development,metabolism
Immunohistochemistry
Interleukin-17/biosynthesis
Male
Rats
Rats, Long-Evans
Receptors, Interleukin-17/biosynthesis
Tibia/growth & development,metabolism
Chemicals
Interleukin-17
Receptors, Interleukin-17
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Kokubu Takeshi
Center for Tissue Regeneration and Repair, Department of Orthopedics, University of California, School of Medicine, 4635 Second Avenue, Sacramento, CA 95817, USA.
Haudenschild Dominik R
Moseley Timothy A
Rose Larry
Reddi A Hari
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