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PMID: 17847006 Published · ppublish English Case Reports Journal Article Research Support, Non-U.S. Gov't

Homozygous mutation in SPATA16 is associated with male infertility in human globozoospermia.

American journal of human genetics ·Vol. 81 ·No. 4 ·2007-10-00 ·Pages 813-20

Dam AH, Koscinski I, Kremer JA, Moutou C, Jaeger AS, Oudakker AR, Tournaye H, Charlet N, Lagier-Tourenne C, van Bokhoven H, Viville S

Abstract

Globozoospermia is a rare (incidence <0.1% in male infertile patients) form of teratozoospermia, mainly characterized by round-headed spermatozoa that lack an acrosome. It originates from a disturbed spermiogenesis, which is expected to be induced by a genetic factor. Several family cases and recessive mouse models with the same phenotype support this expectation. In this study, we present a consanguineous family with three affected brothers, in whom we have identified a homozygous mutation in the spermatogenesis-specific gene SPATA16. This is the first example of a nonsyndromic male infertility condition in humans caused by an autosomal gene defect, and it could also mean that the identification of other partners like SPATA16 could elucidate acrosome formation.

MeSH Terms
Amino Acid Sequence Base Sequence DNA/genetics Female Haplotypes Homeodomain Proteins/genetics Homozygote Humans Infertility, Male/genetics,pathology Male Mutation Pedigree Polymorphism, Single Nucleotide Spermatogenesis/genetics Spermatozoa/abnormalities Vesicular Transport Proteins
Chemicals
Homeodomain Proteins SPATA16 protein, human Vesicular Transport Proteins DNA
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Dam Anika H D M
Centre for Reproduction, Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Koscinski Isabelle
Kremer Jan A M
Moutou Celine
Jaeger Anne-Sophie
Oudakker Astrid R
Tournaye Herman
Charlet Nicolas
Lagier-Tourenne Clotilde
van Bokhoven Hans
Viville Stephane
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
2007-10-00
Epub
2007-00-21
Pages
813-20
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC2227931
Subset
IM
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