Abstract
Globozoospermia is a rare (incidence <0.1% in male infertile patients) form of teratozoospermia, mainly characterized by round-headed spermatozoa that lack an acrosome. It originates from a disturbed spermiogenesis, which is expected to be induced by a genetic factor. Several family cases and recessive mouse models with the same phenotype support this expectation. In this study, we present a consanguineous family with three affected brothers, in whom we have identified a homozygous mutation in the spermatogenesis-specific gene SPATA16. This is the first example of a nonsyndromic male infertility condition in humans caused by an autosomal gene defect, and it could also mean that the identification of other partners like SPATA16 could elucidate acrosome formation.
MeSH Terms
Amino Acid Sequence
Base Sequence
DNA/genetics
Female
Haplotypes
Homeodomain Proteins/genetics
Homozygote
Humans
Infertility, Male/genetics,pathology
Male
Mutation
Pedigree
Polymorphism, Single Nucleotide
Spermatogenesis/genetics
Spermatozoa/abnormalities
Vesicular Transport Proteins
Chemicals
Homeodomain Proteins
SPATA16 protein, human
Vesicular Transport Proteins
DNA
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Dam Anika H D M
Centre for Reproduction, Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Koscinski Isabelle
Kremer Jan A M
Moutou Celine
Jaeger Anne-Sophie
Oudakker Astrid R
Tournaye Herman
Charlet Nicolas
Lagier-Tourenne Clotilde
van Bokhoven Hans
Viville Stephane
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