Extrathymic differentiation of intraepithelial lymphocytes: generation of a separate and unequal T-cell repertoire?

Immunology today ·Vol. 12 ·No. 12 ·1991-12-00 ·Pages 436-8

Lefrançois L

Abstract

A significant number of intraepithelial intestinal T cells appear to mature extrathymically. In this paper, Leo Lefrançois discusses the implication of this for T-cell receptor selection and repertoire generation. He goes on to develop the concept that such cells may constitute discrete subsets of organ-specific lymphocytes, with unique T-cell receptor repertoires that may be evolutionary antecedents of thymus-derived T cells.

MeSH Terms

Animals Autoimmune Diseases/immunology Bone Marrow Transplantation/immunology CD8 Antigens/genetics Cell Differentiation Epithelial Cells Epithelium/immunology Gene Rearrangement, T-Lymphocyte Immune Tolerance Intestinal Mucosa/immunology Intestine, Small/immunology Mice Mice, Nude/immunology Radiation Chimera Receptors, Antigen, T-Cell/genetics T-Lymphocyte Subsets/cytology,immunology

Chemicals

CD8 Antigens Receptors, Antigen, T-Cell

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Lefrançois L

Dept of Cell Biology, Upjohn Company, Kalamazoo, MI 49001.

Article Info

Journal

Immunology today

Abbr.

Immunol Today

ISSN

0167-5699

DOI

10.1016/0167-5699(91)90015-L

Published

1991-12-00

Pages

436-8

Language

English

Region

England

NLM ID

8008346

Subset

Corrections

CommentIn

PMID: 1533766

External Links

PubMed source DOI: 10.1016/0167-5699(91)90015-L

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Extrathymic differentiation of intraepithelial lymphocytes: generation of a separate and unequal T-cell repertoire?

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