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PMID: 17872562 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The IL23 axis plays a key role in the pathogenesis of IBD.

Gut ·Vol. 56 ·No. 10 ·2007-10-00 ·Pages 1333-6

McGovern D, Powrie F

Abstract

Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal inflammation and may open new avenues for development of therapeutic strategies in IBD.

MeSH Terms
Animals Genetic Predisposition to Disease Humans Inflammatory Bowel Diseases/genetics,immunology,therapy Interleukin-12/genetics Interleukin-23/genetics,immunology Mice Receptors, Interleukin/genetics,immunology
Chemicals
IL23R protein, human Interleukin-23 Receptors, Interleukin Interleukin-12
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
McGovern Dermot
Imperial College, London, Hammersmith Hospital Campus Du Cane Road, London W12 0HS, UK. [email protected]
Powrie Fiona
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34 references, click to expand
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Article Info
Journal
Gut
Abbr.
Gut
ISSN
0017-5749
DOI
10.1136/gut.2006.115402
Email
[email protected]
Published
2007-10-00
Pages
1333-6
Language
English
Region
England
NLM ID
2985108R
PMCID
PMC2000291
Subset
IM
External Links
PubMed source DOI: 10.1136/gut.2006.115402 PMC Full Text View journal details
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