Fluorosugars inhibit biological properties of different enveloped viruses.
Both 2-deoxy-2-fluoro-D-glucose and 2-deoxy-2-fluoro-D-mannose were found to be potent inhibitors of the synthesis of infectious Semliki forest and fowl plague virus in chicken embryo cells and also of pseudorabies virus grown in rabbit kidney cells. It was found that the pseudorabies virus-mediated cell fusion and the synthesis of functional hemagglutinin of fowl plague virus were blocked. In all cases the 2-deoxy-2-fluoro-D-mannose-caused inhibition was stronger than the 2-deoxy-2-fluoro-D-glucose- or 2-deoxy-D-glucose-mediated blocks. Studies on the virus-specified proteins from Semiliki forest virus-infected cells grown in the presence of the inhibitors show that the target of the fluorosugar action, parallel to the well-studied effects of 2-deoxy-D-glucose, is the glycoprotein biosynthesis.
18 references, click to expand
-
Monolayer tissue cultures. I. Preparation and standardization of suspensions of trypsin-dispersed monkey kidney cells.Proc Soc Exp Biol Med. 1954 Feb;85(2):202-5 PMID: 13155547
-
Physical and biological properties of influenza virus components obtained after ether treatment.J Exp Med. 1960 Nov 1;112:765-82 PMID: 13719952
-
Inhibition of glycolysis in ascites tumor cells preincubated with 2 -deoxy- 2-fluoro- D -glucose.Biochim Biophys Acta. 1972 Apr 21;264(2):319-27 PMID: 4260430
-
The proteins of the parainfluenza virus SV5. II. The carbohydrate content and glycoproteins of the virion.Virology. 1970 Oct;42(2):473-81 PMID: 4321303
-
Incorporation of 2-deoxy-D-glucose into glucoproteins of normal and Simian virus 40-transformed hamster cells.Cancer Res. 1973 Oct;33(10):2402-7 PMID: 4355025
-
Inhibition of glycosylation of the influenza virus hemagglutinin.J Virol. 1974 Nov;14(5):1023-34 PMID: 4473565
-
Nucleoside-diphosphate derivatives of 2-deoxy-D-glucose in animal cells.Eur J Biochem. 1974 Nov 1;49(1):237-47 PMID: 4477530
-
The use of deoxyfluoro-D-glucopyranoses and related compounds in a study of yeast hexokinase specificity.Biochem J. 1972 Jun;128(2):199-204 PMID: 4563639
-
Lysis of Saccharomyces cerevisiae with 2-deoxy-2-fluoro-D-glucose, an inhibitor of the cell wall glucan synthesis.J Bacteriol. 1973 Sep;115(3):1108-20 PMID: 4580558
-
Inhibition of glycoprotein biosynthesis of influenza virus by D-glucosamine and 2-deoxy-D-glucose.Virology. 1972 Sep;49(3):723-34 PMID: 4672417
-
Effect of 2-deoxy-D-glucose on the multiplication of Semliki Forest virus and the reversal of the block by mannose.Virology. 1973 Jul;54(1):179-89 PMID: 4736595
-
Identification of a precursor for one of the Semliki forest virus membrane proteins.FEBS Lett. 1973 Jan 15;29(2):87-91 PMID: 4737026
-
Some in vivo and in vitro antitumour effects of the deoxyfluoro-D-glucopyranoses.Eur J Cancer. 1973 Jul;9(7):463-70 PMID: 4803223
-
Inhibition of herpes virus-induced cell fusion by concanavalin A, antisera, and 2-deoxy-D-glucose.J Virol. 1974 Aug;14(2):307-14 PMID: 4858786
-
The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers.Biochemistry. 1968 Nov;7(11):4030-4 PMID: 4972613
-
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.Nature. 1970 Aug 15;227(5259):680-5 PMID: 5432063
-
Evaluation of 4-(2-hydroxyethyl)-1-piperazineëthanesulfonic acid (HEPES) as a tissue culture buffer.Proc Soc Exp Biol Med. 1969 Jan;130(1):305-10 PMID: 5762514
-
Inhibition of the multiplication of enveloped viruses by glucose derivatives.Curr Top Microbiol Immunol. 1975;70:101-19 PMID: 808397
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
