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PMID: 17892850 Published · ppublish English Comment Journal Article Review

Foxp3+ regulatory T cells: selfishness under scrutiny.

Immunity ·Vol. 27 ·No. 3 ·2007-09-00 ·Pages 417-9

Stephens GL, Shevach EM

Abstract

The Foxp3+ T cell lineage is thought to arise from self-specific precursors during development. By using a unique mouse model, Pacholczyk et al. (2007) present compelling evidence that self-specific cells are exceedingly rare among Foxp3(-) and, surprisingly, Foxp3+ subsets.

MeSH Terms
Animals Forkhead Transcription Factors/immunology Humans Mice Self Tolerance/immunology T-Lymphocytes, Regulatory/immunology
Chemicals
FOXP3 protein, human Forkhead Transcription Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Stephens Geoffrey L
Cellular Immunology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
Shevach Ethan M
Article Info
Journal
Immunity
Abbr.
Immunity
ISSN
1074-7613
DOI
10.1016/j.immuni.2007.08.008
Published
2007-09-00
Pages
417-9
Language
English
Region
United States
NLM ID
9432918
Subset
IM
Corrections
CommentOn
PMID: 17869133
External Links
PubMed source DOI: 10.1016/j.immuni.2007.08.008 View journal details
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