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PMID: 17907820 Published · ppublish English Comparative Study Journal Article Research Support, N.I.H., Extramural

Food reinforcement, the dopamine D2 receptor genotype, and energy intake in obese and nonobese humans.

Behavioral neuroscience ·Vol. 121 ·No. 5 ·2007-10-00 ·Pages 877-86

Epstein LH, Temple JL, Neaderhiser BJ, Salis RJ, Erbe RW, Leddy JJ

Abstract

The authors measured food reinforcement, polymorphisms of the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes, and laboratory energy intake in 29 obese and 45 nonobese humans 18-40 years old. Food reinforcement was greater in obese than in nonobese individuals, especially in obese individuals with the TaqI A1 allele. Energy intake was greater for individuals high in food reinforcement and greatest in those high in food reinforcement with the TaqI A1 allele. No effect of the DAT1 genotype was observed. These data show that individual differences in food reinforcement may be important for obesity and that the DRD2 genotype may interact with food reinforcement to influence energy intake.

MeSH Terms
Adolescent Adult Anthropometry Body Weight/genetics,physiology DNA/genetics Diet Dopamine Plasma Membrane Transport Proteins/genetics Energy Intake/genetics,physiology Female Food Genotype Humans Hunger/physiology Individuality Male Obesity/genetics,psychology Receptors, Dopamine D2/genetics,physiology Reinforcement, Psychology Reverse Transcriptase Polymerase Chain Reaction Satiety Response/physiology Surveys and Questionnaires
Chemicals
Dopamine Plasma Membrane Transport Proteins Receptors, Dopamine D2 SLC6A3 protein, human DNA
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Epstein Leonard H
Department of Pediatrics, University at Buffalo, State University of New York, Buffalo, NY 14214-3000, USA. [email protected]
Temple Jennifer L
Neaderhiser Brad J
Salis Robbert J
Erbe Richard W
Leddy John J
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Article Info
Journal
Behavioral neuroscience
Abbr.
Behav Neurosci
ISSN
0735-7044
DOI
10.1037/0735-7044.121.5.877
Email
[email protected]
Published
2007-10-00
Pages
877-86
Language
English
Region
United States
NLM ID
8302411
PMCID
PMC2213752
Subset
IM
Grants
NICHD NIH HHS · R01 HD039778 · United States
NICHD NIH HHS · R01 HD039778-06 · United States
NICHD NIH HHS · R01 HD057975 · United States
NICHD NIH HHS · R01 HD 39778 · United States
Corrections
ErratumIn
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External Links
PubMed source DOI: 10.1037/0735-7044.121.5.877 PMC Full Text View journal details
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