Loss of T-bet sends host-microbe mutualism awry.

Cell ·Vol. 131 ·No. 1 ·2007-10-05 ·Pages 15-7

Ma A

Abstract

Immune homeostasis in the intestine involves complex interactions between microbial organisms and host cells. In this issue, Garrett et al. (2007) describe a communicable form of colitis that is induced by deficiency of the transcription factor T-bet in cells of the innate immune system.

MeSH Terms

Animals B-Lymphocytes/immunology Colitis, Ulcerative/immunology Homeodomain Proteins/genetics,metabolism Homeostasis Humans Immunity, Innate/physiology Intestines/immunology,microbiology Mice Mice, Knockout T-Box Domain Proteins/genetics,metabolism T-Lymphocytes/immunology Tumor Necrosis Factor-alpha/immunology

Chemicals

Homeodomain Proteins T-Box Domain Proteins T-box transcription factor TBX21 Tumor Necrosis Factor-alpha RAG-1 protein

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Ma Averil

Department of Medicine, Program in Biomedical Sciences, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0451, USA. [email protected]

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/j.cell.2007.09.030

[email protected]

Published

2007-10-05

Pages

15-7

Language

English

Region

United States

NLM ID

0413066

Subset

Corrections

CommentOn

PMID: 17923086

External Links

PubMed source DOI: 10.1016/j.cell.2007.09.030 View journal details

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