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PMID: 179263 Published · ppublish English Journal Article

Parkinson's disease: distribution of Lewy bodies and monoamine neuron system.

Acta neuropathologica ·Vol. 34 ·No. 4 ·1976-04-26 ·Pages 311-9

Ohama E, Ikuta F

Abstract

A systematic study of the central and peripheral nervous systems in 3 cases of Parkinson's disease has demonstrated that Lewy bodies are present in 27 nuclei. Of these 20 nuclei (12 pigmented and 8 unpigmented) are involved in 2 or all 3 cases. It is noticed that the distribution of Lewy bodies in Parkinson's disease described here corresponds surprisingly well to that of monoamine (dopamine, noradrenaline and serotonin) cell bodies demonstrated in rats by the histochemical fluorescence method. This correlation is similar to that of Alzheimer's neurofibillary changes in postencephalitic Parkinsonism as described by Ishii. Inasmuch as these viewpoints are also in agreement with preciously reported biochemical data on Parkinsonism, it is suggested that Parkinsonism (idiopathic and postencephalitic) should represent a system degeneration of monoamine neuron systems.

MeSH Terms
Biogenic Amines/metabolism Brain Stem/pathology Cytoplasmic Granules Humans Inclusion Bodies Male Middle Aged Nervous System/pathology Neurofibrils Neurons/pathology Parkinson Disease/metabolism,pathology
Chemicals
Biogenic Amines
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ohama E
Ikuta F
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21 references, click to expand
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Article Info
Journal
Acta neuropathologica
Abbr.
Acta Neuropathol
ISSN
0001-6322
DOI
10.1007/BF00696560
Published
1976-04-26
Pages
311-9
Language
English
Region
Germany
NLM ID
0412041
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00696560 View journal details
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