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PMID: 17955331 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The Rotterdam Study: objectives and design update.

European journal of epidemiology ·Vol. 22 ·No. 11 ·2007-00-00 ·Pages 819-29

Hofman A, Breteler MM, van Duijn CM, Krestin GP, Pols HA, Stricker BH, Tiemeier H, Uitterlinden AG, Vingerling JR, Witteman JC

Abstract

The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in the Netherlands. The study targets cardiovascular, neurological, ophthalmological and endocrine diseases. As of 2008 about 15,000 subjects aged 45 years or over comprise the Rotterdam Study cohort. The findings of the Rotterdam Study have been presented in some 600 research articles and reports (see http://www.epib.nl/rotterdamstudy). This article gives the reasons for the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.

MeSH Terms
Aged Aged, 80 and over Cardiovascular Diseases/epidemiology Chronic Disease/epidemiology Cohort Studies Epidemiologic Research Design Genetic Research Humans Mental Disorders/epidemiology Middle Aged Nervous System Diseases/epidemiology Netherlands/epidemiology Pharmacoepidemiology
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Hofman Albert
Department of Epidemiology & Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands. [email protected]
Breteler Monique M B
van Duijn Cornelia M
Krestin Gabriel P
Pols Huibert A
Stricker Bruno H Ch
Tiemeier Henning
Uitterlinden André G
Vingerling Johannes R
Witteman Jacqueline C M
References (87)
87 references, click to expand
  1. Alcohol consumption and risk of dementia: the Rotterdam Study.
    Lancet. 2002 Jan 26;359(9303):281-6 PMID: 11830193
  2. Allelic variants of cytochrome P450 2C9 modify the interaction between nonsteroidal anti-inflammatory drugs and coumarin anticoagulants.
    Clin Pharmacol Ther. 2005 Jun;77(6):479-85 PMID: 15961979
  3. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease.
    N Engl J Med. 2001 Nov 22;345(21):1515-21 PMID: 11794217
  4. The risk of bleeding complications in patients with cytochrome P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol or phenprocoumon.
    Thromb Haemost. 2004 Jul;92(1):61-6 PMID: 15213846
  5. An igf-I gene polymorphism modifies the risk of diabetic retinopathy.
    Diabetes. 2006 Aug;55(8):2387-91 PMID: 16873705
  6. Vitamin B12, folate, and homocysteine in depression: the Rotterdam Study.
    Am J Psychiatry. 2002 Dec;159(12):2099-101 PMID: 12450964
  7. Incidental findings on brain MRI in the general population.
    N Engl J Med. 2007 Nov 1;357(18):1821-8 PMID: 17978290
  8. Use of hippocampal and amygdalar volumes on magnetic resonance imaging to predict dementia in cognitively intact elderly people.
    Arch Gen Psychiatry. 2006 Jan;63(1):57-62 PMID: 16389197
  9. Estrogen receptor alpha gene polymorphisms and risk of myocardial infarction.
    JAMA. 2004 Jun 23;291(24):2969-77 PMID: 15213208
  10. Are retinal arteriolar or venular diameters associated with markers for cardiovascular disorders? The Rotterdam Study.
    Invest Ophthalmol Vis Sci. 2004 Jul;45(7):2129-34 PMID: 15223786
  11. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study.
    Ann Intern Med. 2000 Feb 15;132(4):270-8 PMID: 10681281
  12. Sleep duration and hypertension are not associated in the elderly.
    Hypertension. 2007 Sep;50(3):585-9 PMID: 17635854
  13. Age-related macular degeneration and smoking. The Rotterdam Study.
    Arch Ophthalmol. 1996 Oct;114(10):1193-6 PMID: 8859077
  14. Dietary intake of antioxidants and risk of Alzheimer disease.
    JAMA. 2002 Jun 26;287(24):3223-9 PMID: 12076218
  15. Genetic risk of age-related maculopathy. Population-based familial aggregation study.
    Arch Ophthalmol. 1998 Dec;116(12):1646-51 PMID: 9869796
  16. Causes of incident visual field loss in a general elderly population: the Rotterdam study.
    Arch Ophthalmol. 2005 Feb;123(2):233-8 PMID: 15710821
  17. High serum C-reactive protein level is not an independent predictor for stroke: the Rotterdam Study.
    Circulation. 2006 Oct 10;114(15):1591-8 PMID: 17015791
  18. Corticosteroids and the risk of atrial fibrillation.
    Arch Intern Med. 2006 May 8;166(9):1016-20 PMID: 16682576
  19. Carotid plaques increase the risk of stroke and subtypes of cerebral infarction in asymptomatic elderly: the Rotterdam study.
    Circulation. 2002 Jun 18;105(24):2872-7 PMID: 12070116
  20. Age-specific prevalence and causes of blindness and visual impairment in an older population: the Rotterdam Study.
    Arch Ophthalmol. 1998 May;116(5):653-8 PMID: 9596502
  21. Incidence of dementia: does gender make a difference?
    Neurobiol Aging. 2001 Jul-Aug;22(4):575-80 PMID: 11445258
  22. Retinal vessel diameters and risk of hypertension: the Rotterdam Study.
    Hypertension. 2006 Feb;47(2):189-94 PMID: 16380526
  23. Estrogen receptor alpha gene polymorphisms and anxiety disorder in an elderly population.
    Mol Psychiatry. 2005 Sep;10(9):806-7 PMID: 15940291
  24. Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study.
    Circulation. 2006 Feb 7;113(5):657-63 PMID: 16461838
  25. Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: the Rotterdam Study.
    Neurology. 1994 Jul;44(7):1246-52 PMID: 8035924
  26. Inflammatory proteins and depression in the elderly.
    Epidemiology. 2003 Jan;14(1):103-7 PMID: 12500057
  27. Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam Study.
    Am J Clin Nutr. 2003 Jul;78(1):40-6 PMID: 12816769
  28. Cerebral haemodynamics and depression in the elderly.
    J Neurol Neurosurg Psychiatry. 2002 Jul;73(1):34-9 PMID: 12082042
  29. Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure The Rotterdam Study.
    Eur Heart J. 2004 Sep;25(18):1614-9 PMID: 15351160
  30. Inventory of Complicated Grief: a scale to measure maladaptive symptoms of loss.
    Psychiatry Res. 1995 Nov 29;59(1-2):65-79 PMID: 8771222
  31. Vitamin E and depressive symptoms are not related. The Rotterdam Study.
    J Affect Disord. 2002 Oct;72(1):79-83 PMID: 12204320
  32. Heterogeneity of the genetic risk in age-related macular disease: a population-based familial risk study.
    Ophthalmology. 2005 Mar;112(3):482-7 PMID: 15745778
  33. Relationship between atherosclerosis and late-life depression: the Rotterdam Study.
    Arch Gen Psychiatry. 2004 Apr;61(4):369-76 PMID: 15066895
  34. A common polymorphism in the complement factor H gene is associated with increased risk of myocardial infarction: the Rotterdam Study.
    J Am Coll Cardiol. 2006 Apr 18;47(8):1568-75 PMID: 16630992
  35. Homocysteine levels and the risk of osteoporotic fracture.
    N Engl J Med. 2004 May 13;350(20):2033-41 PMID: 15141041
  36. HMG-CoA reductase inhibitors and the risk of vertebral fracture.
    J Bone Miner Res. 2004 Sep;19(9):1525-30 PMID: 15312254
  37. There is no such thing as aging.
    BMJ. 1997 Oct 25;315(7115):1030-2 PMID: 9366723
  38. Cerebral white matter lesions and depressive symptoms in elderly adults.
    Arch Gen Psychiatry. 2000 Nov;57(11):1071-6 PMID: 11074873
  39. The risk of overanticoagulation in patients with cytochrome P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol or phenprocoumon.
    Pharmacogenetics. 2004 Jan;14(1):27-33 PMID: 15128048
  40. Changing views on open-angle glaucoma: definitions and prevalences--The Rotterdam Study.
    Invest Ophthalmol Vis Sci. 2000 Oct;41(11):3309-21 PMID: 11006219
  41. Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: the Rotterdam Study.
    Lancet. 1998 Jun 20;351(9119):1840-3 PMID: 9652667
  42. Antihypertensive drugs and incidence of dementia: the Rotterdam Study.
    Neurobiol Aging. 2001 May-Jun;22(3):407-12 PMID: 11378246
  43. Incidence, risk, and case fatality of first ever stroke in the elderly population. The Rotterdam Study.
    J Neurol Neurosurg Psychiatry. 2003 Mar;74(3):317-21 PMID: 12588915
  44. Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities Study.
    Ophthalmology. 1999 Dec;106(12):2269-80 PMID: 10599656
  45. Genetic risk of primary open-angle glaucoma. Population-based familial aggregation study.
    Arch Ophthalmol. 1998 Dec;116(12):1640-5 PMID: 9869795
  46. Determinants of disease and disability in the elderly: the Rotterdam Elderly Study.
    Eur J Epidemiol. 1991 Jul;7(4):403-22 PMID: 1833235
  47. Cardiovascular disease and distribution of cognitive function in elderly people: the Rotterdam Study.
    BMJ. 1994 Jun 18;308(6944):1604-8 PMID: 8025427
  48. Prolonged QTc interval and risk of sudden cardiac death in a population of older adults.
    J Am Coll Cardiol. 2006 Jan 17;47(2):362-7 PMID: 16412861
  49. Subclinical atherosclerosis and risk of atrial fibrillation: the rotterdam study.
    Arch Intern Med. 2007 Feb 26;167(4):382-7 PMID: 17325300
  50. Genetic association of apolipoprotein E with age-related macular degeneration.
    Am J Hum Genet. 1998 Jul;63(1):200-6 PMID: 9634502
  51. Demography. Broken limits to life expectancy.
    Science. 2002 May 10;296(5570):1029-31 PMID: 12004104
  52. Lipoprotein-associated phospholipase A2 activity is associated with risk of coronary heart disease and ischemic stroke: the Rotterdam Study.
    Circulation. 2005 Feb 8;111(5):570-5 PMID: 15699277
  53. Silent brain infarcts and the risk of dementia and cognitive decline.
    N Engl J Med. 2003 Mar 27;348(13):1215-22 PMID: 12660385
  54. Patients with an ApoE epsilon4 allele require lower doses of coumarin anticoagulants.
    Pharmacogenet Genomics. 2005 Feb;15(2):69-74 PMID: 15861030
  55. Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study.
    Eur Heart J. 2006 Apr;27(8):949-53 PMID: 16527828
  56. C-reactive protein gene haplotypes and risk of coronary heart disease: the Rotterdam Study.
    Eur Heart J. 2006 Jun;27(11):1331-7 PMID: 16682383
  57. Primary open-angle glaucoma, intraocular pressure, and systemic blood pressure in the general elderly population. The Rotterdam Study.
    Ophthalmology. 1995 Jan;102(1):54-60 PMID: 7831042
  58. Lipoprotein-associated phospholipase A2 activity and risk of heart failure: The Rotterdam study.
    Eur Heart J. 2006 Oct;27(19):2346-52 PMID: 16952920
  59. Test-retest reliability of the computerized DSM-IV version of the Munich-Composite International Diagnostic Interview (M-CIDI).
    Soc Psychiatry Psychiatr Epidemiol. 1998 Nov;33(11):568-78 PMID: 9803825
  60. Overanticoagulation associated with combined use of lactulose and acenocoumarol or phenprocoumon.
    Br J Clin Pharmacol. 2004 Apr;57(4):522-4 PMID: 15025752
  61. Incidence of parkinsonism and Parkinson disease in a general population: the Rotterdam Study.
    Neurology. 2004 Oct 12;63(7):1240-4 PMID: 15477545
  62. GenABEL: an R library for genome-wide association analysis.
    Bioinformatics. 2007 May 15;23(10):1294-6 PMID: 17384015
  63. Age-related macular degeneration is associated with atherosclerosis. The Rotterdam Study.
    Am J Epidemiol. 1995 Aug 15;142(4):404-9 PMID: 7625405
  64. Thiazide diuretics and the risk for hip fracture.
    Ann Intern Med. 2003 Sep 16;139(6):476-82 PMID: 13679324
  65. The prevalence of primary open-angle glaucoma in a population-based study in The Netherlands. The Rotterdam Study.
    Ophthalmology. 1994 Nov;101(11):1851-5 PMID: 7800368
  66. Incidence of open-angle glaucoma in a general elderly population: the Rotterdam Study.
    Ophthalmology. 2005 Sep;112(9):1487-93 PMID: 16039716
  67. Prevalence of Parkinson's disease in the elderly: the Rotterdam Study.
    Neurology. 1995 Dec;45(12):2143-6 PMID: 8848182
  68. Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study.
    Lancet. 1997 Jan 18;349(9046):151-4 PMID: 9111537
  69. Association of 5' estrogen receptor alpha gene polymorphisms with bone mineral density, vertebral bone area and fracture risk.
    Hum Mol Genet. 2003 Jul 15;12(14):1745-54 PMID: 12837697
  70. Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration.
    JAMA. 2006 Jul 19;296(3):301-9 PMID: 16849663
  71. Clinically defined vascular depression in the general population.
    Psychol Med. 2007 Mar;37(3):383-92 PMID: 17076919
  72. An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group.
    Surv Ophthalmol. 1995 Mar-Apr;39(5):367-74 PMID: 7604360
  73. Mortality in patients with hypertension on angiotensin-I converting enzyme (ACE)-inhibitor treatment is influenced by the ACE insertion/deletion polymorphism.
    Pharmacogenet Genomics. 2005 Feb;15(2):75-81 PMID: 15861031
  74. Prevalence of Alzheimer's disease and vascular dementia: association with education. The Rotterdam study.
    BMJ. 1995 Apr 15;310(6985):970-3 PMID: 7728032
  75. The risk of overanticoagulation in patients with heart failure on coumarin anticoagulants.
    Br J Haematol. 2004 Oct;127(1):85-9 PMID: 15384981
  76. Retinal vessel diameters and risk of stroke: the Rotterdam Study.
    Neurology. 2006 May 9;66(9):1339-43 PMID: 16682664
  77. Promoter and 3'-untranslated-region haplotypes in the vitamin d receptor gene predispose to osteoporotic fracture: the rotterdam study.
    Am J Hum Genet. 2005 Nov;77(5):807-23 PMID: 16252240
  78. SCAN. Schedules for Clinical Assessment in Neuropsychiatry.
    Arch Gen Psychiatry. 1990 Jun;47(6):589-93 PMID: 2190539
  79. Cholesterol lowering drugs and risk of age related maculopathy: prospective cohort study with cumulative exposure measurement.
    BMJ. 2003 Feb 1;326(7383):255-6 PMID: 12560276
  80. Association of nonsteroidal anti-inflammatory drugs with first occurrence of heart failure and with relapsing heart failure: the Rotterdam Study.
    Arch Intern Med. 2002 Feb 11;162(3):265-70 PMID: 11822918
  81. Predictive value of noninvasive measures of atherosclerosis for incident myocardial infarction: the Rotterdam Study.
    Circulation. 2004 Mar 9;109(9):1089-94 PMID: 14993130
  82. Association between genetic variation in the gene for insulin-like growth factor-I and low birthweight.
    Lancet. 2002 Mar 23;359(9311):1036-7 PMID: 11937187
  83. Overanticoagulation associated with combined use of antibacterial drugs and acenocoumarol or phenprocoumon anticoagulants.
    Thromb Haemost. 2002 Nov;88(5):705-10 PMID: 12428081
  84. Is there an association between the use of different types of nonsteroidal antiinflammatory drugs and radiologic progression of osteoarthritis? The Rotterdam Study.
    Arthritis Rheum. 2005 Oct;52(10):3137-42 PMID: 16200593
  85. Relationship between refraction and prevalent as well as incident age-related maculopathy: the Rotterdam Study.
    Invest Ophthalmol Vis Sci. 2003 Sep;44(9):3778-82 PMID: 12939291
  86. Overanticoagulation associated with combined use of antifungal agents and coumarin anticoagulants.
    Clin Pharmacol Ther. 2002 Jun;71(6):496-502 PMID: 12087353
  87. Coronary calcification improves cardiovascular risk prediction in the elderly.
    Circulation. 2005 Jul 26;112(4):572-7 PMID: 16009800
Article Info
Journal
European journal of epidemiology
Abbr.
Eur J Epidemiol
ISSN
0393-2990
Published
2007-00-00
Epub
2007-00-23
Pages
819-29
Language
English
Region
Netherlands
NLM ID
8508062
PMCID
PMC2071967
Subset
IM
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