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PMID: 17967409 Published · ppublish English Comment Journal Article Review

T helper 17 cells get the NOD.

Immunity ·Vol. 27 ·No. 4 ·2007-10-00 ·Pages 546-8

Stetson DB, Medzhitov R

Abstract

Interleukin-17 (IL-17)-producing helper T cells play a role in pathogen defense and autoimmunity. In this issue of Immunity, van Beelen et al. (2007) reveal a pathway that elicits potent IL-17 production from memory T cells through activation of the intracellular receptor NOD2.

MeSH Terms
Animals Humans Immunologic Memory Interleukin-17/biosynthesis,immunology Nod2 Signaling Adaptor Protein/metabolism T-Lymphocyte Subsets/immunology,metabolism T-Lymphocytes, Helper-Inducer/immunology,metabolism
Chemicals
Interleukin-17 NOD2 protein, human Nod2 Signaling Adaptor Protein
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Stetson Daniel B
Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. [email protected]
Medzhitov Ruslan
Article Info
Journal
Immunity
Abbr.
Immunity
ISSN
1074-7613
DOI
10.1016/j.immuni.2007.10.005
Email
[email protected]
Published
2007-10-00
Pages
546-8
Language
English
Region
United States
NLM ID
9432918
Subset
IM
Corrections
CommentOn
PMID: 17919942
External Links
PubMed source DOI: 10.1016/j.immuni.2007.10.005 View journal details
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