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PMID: 17990121 Published · ppublish English Journal Article Review

Apoptosis and autophagy: regulatory connections between two supposedly different processes.

Apoptosis : an international journal on programmed cell death ·Vol. 13 ·No. 1 ·2008-01-00 ·Pages 1-9

Thorburn A

Abstract

Apoptosis and autophagy are genetically-regulated, evolutionarily-conserved processes that regulate cell fate. Both apoptosis and autophagy are important in development and normal physiology and in a wide range of diseases. Recent studies show that despite the marked differences between these two processes, their regulation is intimately connected and the same regulators can sometimes control both apoptosis and autophagy. In this review, I discuss some of these findings, which provide possible molecular mechanisms for crosstalk between apoptosis and autophagy and suggest that it may be useful to think of these processes as different facets of the same cell death continuum rather than completely separate processes.

MeSH Terms
Animals Apoptosis/physiology Apoptosis Regulatory Proteins/metabolism Autophagy/physiology Humans Phagosomes/metabolism
Chemicals
Apoptosis Regulatory Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Thorburn Andrew
Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA. [email protected]
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Article Info
Journal
Apoptosis : an international journal on programmed cell death
Abbr.
Apoptosis
ISSN
1360-8185
DOI
10.1007/s10495-007-0154-9
Email
[email protected]
Published
2008-01-00
Pages
1-9
Language
English
Region
Netherlands
NLM ID
9712129
PMCID
PMC2601595
Subset
IM
Grants
NCI NIH HHS · P30 CA046934 · United States
NCI NIH HHS · R01 CA111421 · United States
NCI NIH HHS · R01 CA111421-04 · United States
External Links
PubMed source DOI: 10.1007/s10495-007-0154-9 PMC Full Text View journal details
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