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PMID: 179949 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Genetic control of natural immunity to ecotropic mouse leukemia viruses: immune response genes.

Infection and immunity ·Vol. 13 ·No. 4 ·1976-04-00 ·Pages 1098-102

Nowinski RC

Abstract

Humoral immune response to ectropic leukemia viruses in AKR and C57BL/6 mice was controlled by a gene that mapped in linkage group IX. Mice of the AKR strain had an immune nonresponsive allele of this gene, whereas mice of the C57BL/6 strain had an immune responsive allele. Antibody against murine leukemia virus (MuLV) reacted primarily with p15 protein of the viral envelope. It was concluded that the failure to find antibody production in AKR mice was the result of a genetic immunological defect, rather than the result of immunological tolerance that was induced by the persistent viremia of endogenous MuLV.

MeSH Terms

Animals Antibodies, Viral/analysis Chromosome Mapping Crosses, Genetic Immunity Leukemia Virus, Murine/immunology Mice Mice, Inbred AKR Mice, Inbred C57BL Peptides/analysis Viral Proteins/analysis

Chemicals

Antibodies, Viral Peptides Viral Proteins

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Nowinski R C

References (12)

12 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.13.4.1098-1102.1976

Published

1976-04-00

Pages

1098-102

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC420723

Subset

External Links

PubMed source DOI: 10.1128/iai.13.4.1098-1102.1976 PMC Full Text View journal details

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Genetic control of natural immunity to ecotropic mouse leukemia viruses: immune response genes.

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