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PMID: 18023168 Published · ppublish English Journal Article Review

Serum response factor micromanaging cardiogenesis.

Current opinion in cell biology ·Vol. 19 ·No. 6 ·2007-12-00 ·Pages 618-27

Niu Z, Li A, Zhang SX, Schwartz RJ

Abstract

Serum response factor (SRF), a cardiac-enriched transcription factor, is required for the appearance of beating sarcomeres in the heart. SRF may also direct the expression of microRNAs (miRs) that inhibit the expression of cardiac regulatory factors. The recent knockout of miR-1-2, an SRF gene target, showed defective heart development, caused in part by the induction of GATA6, Irx4/5, and Hand2, that may alter cardiac morphogenesis, channel activity, and cell cycling. SRF and cofactors play an obligatory role in cardiogenesis, as major determinants of myocyte differentiation not only by regulating the biogenesis of muscle contractile proteins but also by driving the expression of silencer miRNA.

MeSH Terms
Animals Cell Differentiation Gene Expression Regulation Heart/embryology,physiology Humans MicroRNAs/physiology Organogenesis Serum Response Factor/physiology
Chemicals
MicroRNAs Serum Response Factor
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Niu Zhivy
Program in Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA.
Li Ankang
Zhang Shu X
Schwartz Robert J
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
0955-0674
DOI
10.1016/j.ceb.2007.09.013
Published
2007-12-00
Epub
2007-00-26
Pages
618-27
Language
English
Region
England
NLM ID
8913428
PMCID
PMC2735128
Subset
IM
Grants
NHLBI NIH HHS · P01 HL049953-15 · United States
NHLBI NIH HHS · P01 HL049953-14 · United States
NHLBI NIH HHS · P01 HL049953-11 · United States
NHLBI NIH HHS · P01 HL049953-12 · United States
NHLBI NIH HHS · R01 HL079628-03 · United States
NHLBI NIH HHS · P01 HL049953-150001 · United States
NHLBI NIH HHS · P01 HL049953-13 · United States
External Links
PubMed source DOI: 10.1016/j.ceb.2007.09.013 PMC Full Text View journal details
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