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PMID: 180258 Published · ppublish English Case Reports Journal Article

Metronidazole neuropathy.

Journal of neurology, neurosurgery, and psychiatry ·Vol. 39 ·No. 4 ·1976-04-00 ·Pages 403-5

Coxon A, Pallis CA

Abstract

Two patients are described who developed sensory neuropathy after the ingestion of 30.6 and 114 g metronidazole respectively. The drug, widely used in gastroenterological and gynaecological practice, has not hitherto been considered neurotoxic. The implications are stressed in relation to the differential diagnosis of patients with gastroenterological disorders who develop peripheral neuropathy.

MeSH Terms
Adult Crohn Disease/drug therapy Diagnosis, Differential Electrodiagnosis Female Humans Male Metronidazole/adverse effects Middle Aged Paresthesia/chemically induced Peripheral Nervous System Diseases/chemically induced,diagnosis
Chemicals
Metronidazole
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Coxon A
Pallis C A
References (8)
8 references, click to expand
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    Br J Prev Soc Med. 1975 Sep;29(3):157-69 PMID: 127638
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    J Neurol Neurosurg Psychiatry. 1958 May;21(2):109-18 PMID: 13539652
  3. The range of conduction velocity in normal motor nerve fibers to the small muscles of the hand and foot.
    J Neurol Neurosurg Psychiatry. 1959 Aug;22:175-81 PMID: 13838014
  4. Endocrine ophthalmopathy.
    Br Med J. 1968 Dec 14;4(5632):706 PMID: 4301983
  5. Activity of metronidazole against experimental tetanus and gas gangrene.
    J Appl Bacteriol. 1968 Dec;31(4):443-7 PMID: 4302783
  6. Metronidazole for Crohn's disease.
    Lancet. 1975 Apr 5;1(7910):775-7 PMID: 48003
  7. Letter: "High-dose" metronidazole: a preliminary pharmacological study prior to its investigational use in clinical radiotherapy trials.
    Br J Radiol. 1974 May;47(557):297-9 PMID: 4830160
  8. Immunoglobulin deficiency and regional enteritis.
    Scand J Gastroenterol. 1972;7(3):233-6 PMID: 5034529
Article Info
Journal
Journal of neurology, neurosurgery, and psychiatry
Abbr.
J Neurol Neurosurg Psychiatry
ISSN
0022-3050
Published
1976-04-00
Pages
403-5
Language
English
Region
England
NLM ID
2985191R
PMCID
PMC492292
Subset
IM
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